| structure name | NEW INSIGHTS INTO THE ROLE OF DNA SHAPE ON ITS RECOGNITION BY P53 PROTEINS (COMPLEX P53DBD-P53R2) (Cellular tumor antigen p53) |
| reference | Rozenberg et al. Structure 26 1237 2018 |
| source | Homo sapiens |
| experiment | X-ray (resolution=1.45, R-factor=0.172) |
| structural superfamily | p53-like transcription factors; |
| sequence family | P53 DNAbinding domain; |
| redundant complexes | 5mcv 4ibw 3igk 3d0a 5mct 3igl 2ac0 3kz8 5mcw 5mcu 4ibu 4ibv 2ady 2ahi 6fj5 3kmd 2ata 5mf7 4hje 5lgy 1tsr 1tup |
| links to other resources | NAKB  PDIdb DNAproDB |
| protein sequence |
No structural evidence for specific binding to DNA (<4 informative columns)
Related DNA sequences reported in the literature ?
| site | source | matches (E-value) |
|---|---|---|
| term: P53 | ||
| AGACATGCCTAGACATGCCT | PubMed | 2ady_AB(7.87e-05), 6fj5_ABCD(1.55e-15), 3kmd_B(9.54e-04) |
| TGCCT | PubMed | 1tup_BC(1.53e-04), 2ac0_AC(7.13e-03), 3d0a_AC(7.19e-03), ... (total=10) |
| GGGCGT | PubMed | 1tup_BC(4.56e-04) |
| GTAGCATTAGCCCAGACATGTCC | PubMed | 2ady_AB(2.96e-12), 3kmd_ABCD(1.46e-05), 4hje_ABCD(2.72e-03), ... (total=7) |
| CCCGGG | PubMed | 2ac0_AC(2.20e-04), 3d0a_AC(1.64e-04) |
| GTAGGATTAGCCCAGACATGTCC | PubMed | 2ady_AB(2.96e-12), 3kmd_ABCD(1.46e-05), 4hje_ABCD(2.53e-05), ... (total=7) |
| GCGGGGGCG | PubMed | 1tup_BC(3.58e-03), 2ac0_AC(3.43e-04), 3d0a_AC(2.71e-04) |
| GTAGCATTAGCCCAGACATCTCC | PubMed | 2ady_AB(2.33e-07), 3kmd_ABCD(2.75e-03) |
| GAACA | PubMed | 2ady_B(1.17e-03), 1tsr_B(6.10e-03), 1tup_B(1.17e-03) |
Dendrogram of similar interfaces ?
matrix formatKG------RG----ATCTRG L +----3q05_B +------3 --------RG----AGCCRG L ! +----3exj_A +---------4 KGST--------------RA ! ! +5mg7_A ! +----------2 --------RG----ATCTRG +--5 ! +5kbd_B ! ! +-1 --------------ATCTRG ! ! +3qyn_C +---6 ! ----RGRT------VC---- L ! ! +---------------------4l0y_A --7 ! ----RG----TCSC------ ! +------------------------2x6v_A ! ------TT------------ L +----------------------------1a66_A |
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updated Mon Dec 18 13:19:11 2023