interface graph thumbnail
legend  pdf

structure nameSTRUCTURE OF DNMT3A (R882H) IN COMPLEX WITH CAG DNA
(DNA CYTOSINE-5-METHYLTRANSFERASE 3A)
referenceAnteneh et al. 'Nat 11 2294 2020
sourceHOMO SAPIENS
experimentX-ray (resolution=2.44, R-factor=0.185)
structural superfamilyS-adenosyl-L-methionine-dependent methyltransferases;
sequence familyC5 cytosinespecific DNA methylase 541;
multimeric complexes5yx2_AD 6brr_AD 6w89_AD 6w89_GJ 6w8b_AD 6w8b_HK 6w8d_AD 6w8j_AD
reference complex6w8b_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureIVPTRN

Estimated binding specificities ?

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# IC=2.032 IC/col=0.508 n_of_columns=4 specificity:   
A |   9  81   7  19
C |   9   7   4  19
G |  67   4  81  19
T |  11   4   4  39
scan!

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updated Mon Dec 18 18:53:33 2023