6brr_AD : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF DNMT3A (R836A)-DNMT3L IN COMPLEX WITH DNA CONTAINING TWO CPG SITES
reference	Zhang et al. Nature 554 387 2018
source	HOMO SAPIENS
experiment	X-ray (resolution=2.97, R-factor=?)
structural superfamily	S-adenosyl-L-methionine-dependent methyltransferases;
reference complex	6w8b_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6brr_A interface=88,89,90,91,207,208,209,210,211, aekrkpirvlslfdgiatgllvlkdlgiqvdryiasevcedsitvgmvrhqgkimyvgdvrsvtqkhiqewgpfdlviggspcndlsIVNParkglyegtgrlffefyrllhdarpkegddrpffwlfenvvamgvsdkrdisrflesnpvmidakevsaahraryfwgnlpgmnrplastvndklelqeclehgriakfskvrtiTTASNsikqgkdqhfpvfmnekedilwctemervfgfpvhytdvsnmsrlarqrllgrswsvpvirhlfaplkeyfacv > 6brr_D interface=88,89,90,91,207,208,209,210,211,256, aekrkpirvlslfdgiatgllvlkdlgiqvdryiasevcedsitvgmvrhqgkimyvgdvrsvtqkhiqewgpfdlviggspcndlsIVNParkglyegtgrlffefyrllhdarpkegddrpffwlfenvvamgvsdkrdisrflesnpvmidakevsaahraryfwgnlpgmnrplastvndklelqeclehgriakfskvrtiTTASNsikqgkdqhfpvfmnekedilwctemervfgfpvhytdvsnmsrLarqrllgrswsvpvirhlfaplkeyfacv
interface signature	IVNPTTASN/IVNPTTASNL

Estimated binding specificities ?

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# IC=10.842 IC/col=0.678 n_of_columns=16

specificity:

A |   0   0  24  15   0   9  24  24  24  24  86   0  92  61   0   0
C |   0   0  24  13  89  13  24  24  24  24   3   0   0  13  96  93
G |  96  96  24   9   3   3  24  24  24  24   3  96   0   9   0   0
T |   0   0  24  59   4  71  24  24  24  24   4   0   4  13   0   3

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updated Sat Dec 16 08:32:35 2023