structure name | CRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE II BETA IN COMPLEX WITH DNA: A NEW QUATERNARY CONFORMATION SHOWING OPENING OF THE PROTEIN-LINKED DNA-GATE (DNA topoisomerase 2-beta) |
reference | Chen et al. 'Nat 9 3085 2018 |
source | Homo sapiens |
experiment | X-ray (resolution=2.75, R-factor=0.224) |
structural superfamily | Type II DNA topoisomerase; |
sequence family | DNA gyrase/topoisomerase IV, subunit A; |
multimeric complexes | 4g0u_AB 4g0v_AB 4g0w_AB |
redundant complexes | 5zqf |
reference complex | 3qx3_B |
links to other resources | NAKB PDIdb DNAproDB |
protein sequence | |
interface signature | KAIA |
Estimated binding specificities ?
readout + contact |
A | 13 13 24 0 0 C | 13 57 24 96 0 G | 54 13 24 0 96 T | 16 13 24 0 0scan! |
Dendrogram of similar interfaces ?
matrix formatRAKG----------QAAG------IGAG---------------- L +------5zen_A +---2 --KA------------SA--RG--IG------------------ ! +------2xcr_U +----------------4 ----RC----------ST------IA------------------ ! ! +-3ksb_B +-6 +--------1 ------------------------------------LAECDAKG ! ! +-6n1p_A ! ! ------QA--------------NG-------------------- +-7 +---------------------------7k63_U ! ! ----------RC----------SG-------------------- ! ! +-------------------7cow_T ! +--------5 --------RC---------------------------------- --8 ! +--------6l9z_S ! +----------3 ----------DTRGRCTTKT------------------------ L ! +--------2o9l_A ! ----------------------------NCATSTRA-------- +-----------------------------1a02_J |
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updated Mon Dec 18 14:17:22 2023