4g0w_AB : 3D-footprint complex

structure name	HUMAN TOPOISOMERASE IIBETA IN COMPLEX WITH DNA AND AMETANTRONE
reference	Chan et al. 'Nucleic 41 10630 2013
source	Homo sapiens
experiment	X-ray (resolution=2.70, R-factor=?)
structural superfamily	Type II DNA topoisomerase;
reference complex	3qx3_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4g0w_A interface=52,54,212,215,216,264,265,306,358,363, kgipklddandaggkhslectliltegdsakslavsglgvigrdrygvfplRgKilnvreashkqimenaeinniikivglqykksyddaeslktlrygkimimtdqdqdgshikgllinfihhnwpsllkhgfleefitadmerhrilfryagpeddaaitlafskkkiddrkewltnfmedrrqrrlhglkhltyndfinkelilfsnsDneRSipslvdgfkpgqrkvlftcfkrndkrevkvaqlagsvaemsayhhgeQAlmmtivnlaqnfvgsnninllqpigqfgtrlhggkdaaspRyiftmlstlarllfpavddnllkflyddnqrvepewyipiipmvlingaegIgtgwAcklpnydareivnnvrrmldgldphpmlpnyknfkgtiqelgqnqyavsgeifvvdrntveitelpvrtwtqvykeqvlepmlngtdktpalisdykeyhtdttvkfvvkmteeklaqaeaaglhkvfklqttltcnsmvlfdhmgclkkyetvqdilkeffdlrlsyyglrkewlvgmlgaestklnnqarfilekiqgkitienrskkdliqmlvqrgyesdpvkawkeaqegpdfnyilnmslwsltkekveelikqrdakgrevndlkrkspsdlwkedlaafveeldkvesqered > 4g0w_B interface=55,57,172,217,220,221,269,270,361,363,368, skikgipklddandaggkhslectliltegdsakslavsglgvigrdrygvfplRgKilnvreashkqimenaeinniikivglqykksyddaeslktlrygkimimtdqdqdgshikgllinfihhnwpsllkhgfleefitpfadmerhrilfryagpeddaaitlafsKkkiddrkewltnfmedrrqrrlhgtkhltyndfinkelilfsnsDneRSipslvdgfkpgqrkvlftcfkrndkrevkvaqlagsvaemsayhhgeQAlmmtivnlaqnfvgsnninllqpigqfgtrlhggkdaaspryiftmlstlarllfpavddnllkflyddnqrvepewyipiipmvlingaEgIgtgwAcklpnydareivnnvrrmldgldphpmlpnyknfkgtiqelgqnqyavsgeifvvdrntveitelpvrtwtqvykeqvlepmlngpalisdykeyhtdttvkfvvkmteeklaqaeaaglhkvfklqttltcnsmvlfdhmgclkkyetvqdilkeffdlrlsyyglrkewlvgmlgaestklnnqarfilekiqgkitienrskkdliqmlvqrgyesdpvkawkeaqgpdfnyilnmslwsltkekveelikqrdakgrevndlkrkspsdlwkedlaafveeldkvesqered
interface signature	RKDRSQARIA/RKKDRSQAEIA

Estimated binding specificities ?

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# IC=11.361 IC/col=0.812 n_of_columns=14

specificity:

A |   0   0  24   6  24   0   0   6  96  24   0  24   0   0
C |  96   0  24   6  24   0   6  72   0  24  72  60  96   0
G |   0  96  24  78  24   0  90  12   0  24  12   6   0  96
T |   0   0  24   6  24  96   0   6   0  24  12   6   0   0

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updated Fri Dec 15 18:57:11 2023