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structure nameCRYSTAL STRUCTURE OF DNMT3A-DNMT3L IN COMPLEX WITH DNA CONTAINING TWO CPG SITES
(DNA CYTOSINE-5-METHYLTRANSFERASE 3A)
referenceZhang et al. Nature 554 387 2018
sourceHOMO SAPIENS
experimentX-ray (resolution=2.65, R-factor=0.192)
structural superfamilyS-adenosyl-L-methionine-dependent methyltransferases;
sequence familyC5 cytosinespecific DNA methylase 579;
multimeric complexes5yx2_AD 6brr_AD 6w89_AD 6w89_GJ 6w8b_AD 6w8b_HK 6w8d_AD 6w8j_AD
reference complex6w8b_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureIVNPTRSNL

Estimated binding specificities ?

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# IC=4.733 IC/col=0.789 n_of_columns=6 specificity:   
A |   4  48  81   0   0  62
C |   4  14   4  96  96   9
G |  81  14   7   0   0   6
T |   7  20   4   0   0  19
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updated Mon Dec 18 14:11:08 2023