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structure nameK. PNEUMONIAE TOPOISOMERASE IV (PARE-PARC) IN COMPLEX WITH DNA AND (3S)-10-[(3R)-3-(1-AMINOCYCLOPROPYL)PYRROLIDIN-1-YL]-9-FLUORO-3- METHYL-5-OXO-2,3-DIHYDRO-5H-[1,4]OXAZINO[2,3,4-IJ]QUINOLINE-6- CARBOXYLIC ACID (COMPOUND 25)
referenceBellamacina et al. J.Med.Chem. 64 6329 2021
experimentX-ray (resolution=3.30, R-factor=0.284)
structural superfamilyType II DNA topoisomerase;
sequence familyDNA gyrase/topoisomerase IV, subunit A; DNA gyrase B subunit, carboxyl terminus;
multimeric complexes5eix_BJ 6waa_BD 6waa_FH 7lhz_AB
reference complex6waa_D
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKRAEI

Estimated binding specificities ?

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# IC=4.475 IC/col=0.895 n_of_columns=5 specificity:   
A |  54   0  57   0  96
C |  16   0  13  96   0
G |  13   0  13   0   0
T |  13  96  13   0   0
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updated Mon Dec 18 20:52:02 2023