structure name | K. PNEUMONIAE TOPOISOMERASE IV (PARE-PARC) IN COMPLEX WITH DNA AND COMPOUND 34 (7-[(1S,5R)-1-AMINO-3-AZABICYCLO[3.1.0]HEXAN-3-YL]-4- (AMINOMETHYL)-1-CYCLOPROPYL-3,6-DIFLUORO-8-METHYLQUINOLIN-2(1H)-ONE) (DNA TOPOISOMERASE 4 SUBUNIT B,DNA TOPOISOMERASE ATP-...) |
reference | Bellamacina et al. J.Med.Chem. 63 7773 2020 |
source | KLEBSIELLA PNEUMONIAE 342 |
experiment | X-ray (resolution=3.20, R-factor=0.275) |
structural superfamily | Type II DNA topoisomerase; |
sequence family | DNA gyrase/topoisomerase IV, subunit A; DNA gyrase B subunit, carboxyl terminus; |
multimeric complexes | 5eix_BJ 6waa_BD 6waa_FH 7lhz_AB |
redundant complexes | 5eix_G 7lhz_D |
links to other resources | NAKB PDIdb DNAproDB |
protein sequence | |
interface signature | KKYSAIR |
Estimated binding specificities ?
readout + contact |
A | 73 9 73 0 96 73 C | 9 7 14 96 0 9 G | 7 7 7 0 0 7 T | 7 73 2 0 0 7scan! |
Dendrogram of similar interfaces ?
matrix format--KTKAYA--------SGAA------------------IC--RA------------------ L +6waa_D +-4 --KT------RC------AT------------------IC--RG------------------ L +-6 +2xkk_C ! ! --KA--------------SA------------RG----IG---------------------- +---7 +2xcr_U ! ! RCKT--------------SA------------RG----IG---------------------- L +-10 +-5npk_d ! ! --KA----DC--------------------------ECIGSG-------------------- L ! ! +--4fm9_A +-------------13 +--8 --KT--------------SA----------------EGIGSC-------------------- ! ! +--3l4j_A ! ! ------YC----------SG------------RT----IG---------------------- ! ! +5iwi_C ! +--------1 ------YT----------ST--------------RA--IG---------------------- ! +5bs8_A +-16 --KT--YC----------SA------------RG----IC---------------------- L ! ! +-------4z4q_B ! ! +-12 --------------------------------------IA---------------------- ! ! +-----14 +-------4z2c_B ! ! ! ! --KG--------------AG------------RT--ECIGAG-------------------- +-17 +-----15 +---------3qx3_B ! ! ! ----------RC----STSA------------RG----IC---------------------- ! ! ! +3k9f_B ! ! +----------------3 --------------------------------------IG---------------------- ! ! +6rku_A +-18 ! --KG---------------------------------------------------------- ! ! +------------------------5iwi_D ! ! --KT---------------------------------------------------------- ! ! +3k9f_C +-19 ! +--5 --KT---------------------------------------------------------- ! ! +----------------------9 +5bs8_D ! ! ! --KT---------------------------------------------------------- ! ! +---4z2c_D +-20 ! --------------------NASTRGHTSTLT------------------------------ L ! ! +----------------------------7cby_C ! ! ----------------------------------------------NT--ATAT--STRG-- L +-21 ! +1dh3_C ! ! +-----------------------------2 ----------------------------------------------NCRTATAT--STRG-- ! ! +1t2k_D +-22 ! ----------------------------------------------NT--ATAT----RG-- L ! ! +-----------------------------5t01_B +-23 ! ------------PG------------------------------------------------ ! ! +-----------------------------6la8_S ! ! --------------RCQG----------------SG-------------------------- +-24 +-----------------------------4qlc_U ! ! --------------------------YG---------------------------------- ! ! +------1sfu_A -25 +---------------------11 --------------------------YG---------------------------------- ! +------2heo_D ! --------------------------------------------RG----NT--ATAT--RG L +-----------------------------5vpe_C |
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updated Tue Dec 19 15:42:03 2023