3mlp_F : 3D-footprint complex

structure name	EARLY B-CELL FACTOR 1 (EBF1) BOUND TO DNA (Transcription factor COE1)
reference	Grosschedl et al. 'Genes 24 2270 2010
source	Mus musculus
experiment	X-ray (resolution=2.80, R-factor=0.207)
structural superfamily	E set domains;
sequence family	IPT/TIG domain;
multimeric complexes	3mlp_EF
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 3mlp_F interface=28,30,31,128,137,167,169,201,202,203,204, vldantaaqsgvglarahfekqppsnlRkSNffhfvlalydrqgqpveiertafvgfvekekeansektnngihyrlqllysngirteqdfyvrlidsmtkqaivyegqdknpemcrvlltheimcsRccdkkscgNrnetpsdpviidrfflkfflkcnqnclknAgNprdmrrfqvvvsttvnvdghvlavsdnmfvhNNSKhgseaatpcikaispsegwttggatviiigdnffdglqvifgtmlvwselitphairvqtpprhipgvvevtlsykskqfckgtpgrfiytaln
interface signature	RSNRNANNNSK

Estimated binding specificities ?

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# IC=5.807 IC/col=0.581 n_of_columns=10

specificity:

A |  13  24   0   0   0  96  24  24  24  13
C |  13  24  96  96  96   0  24  24  24  16
G |  13  24   0   0   0   0  24  24  24  54
T |  57  24   0   0   0   0  24  24  24  13

scan!

Dendrogram of similar interfaces ?

matrix format

  
  RGSTNTRCNCATNTNCNTSGKG--------   L                     +--------3mlp_F    
                                       +-----------------1 
  RGSTNTRCNGATNANCNTSGKG--------   L   !                 +--------3mln_A    
                                     --4 
  ------------------------KT----   L   !         +----------------2ram_A    
                                       +---------3 
  ----------------------QA------   L             !   +------------1imh_C    
                                                 +---2 
  --------------------------KARC   L                 +------------1p7h_L

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updated Tue Dec 19 07:51:01 2023