interface graph thumbnail
legend  pdf

structure nameDNA GYRASE COMPLEXED WITH UNCLEAVED DNA AND COMPOUND 7 TO 2.6A RESOLUTION
(DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT A)
referenceRatigan et al. J.Med.Chem. 64 15214 2021
sourceSTAPHYLOCOCCUS AUREUS
experimentX-ray (resolution=2.60, R-factor=0.197)
structural superfamilyType II DNA topoisomerase;
sequence familyDNA gyrase/topoisomerase IV, subunit A; DNA gyrase B subunit, carboxyl terminus; Toprim domain;
multimeric complexes2xcs_BD 4bul_AC 4plb_BD 5bs3_BD 5npk_bd 6fm4_BD 7mvs_AB
reference complex5npk_d
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKSERI

Estimated binding specificities ?

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# IC=4.013 IC/col=0.803 n_of_columns=5 specificity:   
A |   0   0  26  87  28
C |  96   0  17   0   8
G |   0  96  19   0  52
T |   0   0  34   9   8
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updated Mon Dec 18 21:11:40 2023