7mvs_AB : 3D-footprint complex

structure name	DNA GYRASE COMPLEXED WITH UNCLEAVED DNA AND COMPOUND 7 TO 2.6A RESOLUTION
reference	Ratigan et al. J.Med.Chem. 64 15214 2021
source	STAPHYLOCOCCUS AUREUS
experiment	X-ray (resolution=2.60, R-factor=?)
structural superfamily	Type II DNA topoisomerase;
reference complex	5npk_d
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7mvs_A interface=45,217,269,272,357,359, gkladcsskspeeceiflvegdsaggstksgrdsrtqailplrgKilnvekarldrilnnneirqmitafgtgiggdfdlakaryhkivimtdadvdgahirtllltffyrfmrplieagyvyiaqpptgykglgemnadqlwettmnpehrallqvkledaieadqtfemlmgdvvenrrqfiednavyarinernitsemresfldyamsvivaRalpdvrdglkpvhrrilyglneqgmtpdksykksarivgdvmgkyhphgdsSiyEamvrmaqdfsyryplvdgqgnfgsmdgdgaaamrftearmtkitlellrdinkdtidfidnydgnerepsvlparfpnllangaSgIavgmatnipphnltelingvlslsknpdisiaelmediegpdfptaglilgksgirrayetgrgsiqmrsravieergggrqrivvteipfqvnkarmiekiaelvrdkkidgitdlrdetslrtgvrvvidvrkdanasvilnnlykqtplqtsfgvnmialvngrpklinlkealvhylehqktvvrrrtqynlrkakdrahileglrialdhideiistiresdtdkvameslqqrfklsekqaqaildmrlrrltglerdkieaeynellnyiseletiladeevllqlvrdelteirdrfgddrrteiql > 7mvs_B interface=44,270,273,277,360, kladcsskspeeceiflvegdsaggstksgrdsrtqailplrgKilnvekarldrilnnneirqmitafgtgiggdfdlakaryhkivimtdadvdgahirtllltffyrfmrplieagyvyiaqpptgykglgemnadqlwettmnpehrallqvkledaieadqtfemlmgdvvenrrqfiednavyansrinernitsemresfldyamsvivaralpdvrdglkpvhrrilyglneqgmtpdksykksarivgdvmgkyhphgdsSiyEamvRmaqdfsyryplvdgqgnfgsmdgdgaaamrftearmtkitlellrdinkdtidfidnydgnerepsvlparfpnllangasgIavgmatnipphnltelingvlslsknpdisiaelmediegpdfptaglilgksgirrayetgrgsiqmrsravieergggrqrivvteipfqvnkarmiekiaelvrdkkidgitdlrdetslrtgvrvvidvrkdanasvilnnlykqtplqtsfgvnmialvngrpklinlkealvhylehqktvvrrrtqynlrkakdrahileglrialdhideiistiresdtdkvameslqqrfklsekqaqaildmrlrrltglerdkieaeynellnyiseletiladeevllqlvrdelteirdrfgddrrteiql
interface signature	KRSESI/KSERI

Estimated binding specificities ?

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# IC=7.601 IC/col=0.543 n_of_columns=14

specificity:

A |   0   0  24  82   6  24  24  24  24  13   6  24   0   0
C |  96   0  24   6   6  24  24  24  24  61   9  24  96   0
G |   0  96  24   0  68  24  24  24  24  13   6  24   0  96
T |   0   0  24   8  16  24  24  24  24   9  75  24   0   0

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updated Sun Dec 17 07:24:12 2023