7fvt_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF S. AUREUS GYRASE IN COMPLEX WITH 6-[5-[2-[(4- CHLORO-2,3-DIHYDRO-1H-INDEN-2-YL)METHYLAMINO]ETHYL]-2-OXO-1,3- OXAZOLIDIN-3-YL]-4H-PYRIDO[3,2-B][1,4]OXAZIN-3-ONE
reference	'Acs 2023 X-RAY DIFFRACTION
experiment	X-ray (resolution=2.08, R-factor=0.202)
structural superfamily	Type II DNA topoisomerase;
sequence family	DNA gyrase/topoisomerase IV, subunit A; DNA gyrase B subunit, carboxyl terminus; Toprim domain;
multimeric complexes	2xcs_BD 4bul_AC 4plb_BD 5bs3_BD 5npk_bd 6fm4_BD 7mvs_AB
reference complex	5npk_d
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7fvt_A interface=42,44,205,264,265,302,355, kladcsskspeeceiflvegdsaggstksgrdsrtqailplRgKilnvekarldrilnnneirqmitafgtgiggdfdlakaryhkivimtdadvdgahirtllltffyrfmrplieagyvyiaqpptgykglgemnadqlwettmnpehrallqvkledaieadqtfemlmgdvvenrrqfiednavynernitsemresfldYamsvivaralpdvrdglkpvhrrilyglneqgmtpdksykksarivgdvmgkyhphgdSSiyeamvrmaqdfsyryplvdgqgnfgsmdgdgaaamRftearmtkitlellrdinkdtidfidnydgnerepsvlparfpnllangasgIavgmatnipphnltelingvlslsknpdisiaelmediegpdfptaglilgksgirrayetgrgsiqmrsravieergggrqrivvteipfqvnkarmiekiaelvrdkkidgitdlrdetslrtgvrvvidvrkdanasvilnnlykqtplqtsfgvnmialvngrpklinlkealvhylehqktvvrrrtqynlrkakdrahileglrialdhideiistiresdtdkvameslqqrfklsekqaqaildmrlrrltglerdkieaeynellnyiseletiladeevllqlvrdelteirdrfgddrrteiql
interface signature	RKYSSRI

Estimated binding specificities ?

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# IC=2.663 IC/col=0.140 n_of_columns=19

specificity:

A |  24  24  24   0   2  24  45  16  22  21  24  22  24  24  24  24  24  24  24
C |  24  24  24  96   2  24  16  16  22  21  24  27  24  24  24  24  24  24  24
G |  24  24  24   0  90  24  19  48  27  31  24  22  24  24  24  24  24  24  24
T |  24  24  24   0   2  24  16  16  25  23  24  25  24  24  24  24  24  24  24

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updated Mon Dec 18 20:12:15 2023