7fvs_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF S. AUREUS GYRASE IN COMPLEX WITH 4-[[1-[(1- CHLORO-6,7-DIHYDRO-5H-CYCLOPENTA[C]PYRIDIN-6-YL)METHYL]AZETIDIN-3- YL]METHYLAMINO]-6-FLUOROCHROMEN-2-ONE
reference	'Acs 2023
experiment	X-ray (resolution=2.16, R-factor=0.191)
structural superfamily	Type II DNA topoisomerase;
sequence family	DNA gyrase/topoisomerase IV, subunit A; DNA gyrase B subunit, carboxyl terminus; Toprim domain;
multimeric complexes	2xcs_BD 4bul_AC 4plb_BD 5bs3_BD 5npk_bd 6fm4_BD 7mvs_AB
reference complex	5npk_d
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7fvs_A interface=44,205,213,264,265,302,355, kladcsskspeeceiflvegdsaggstksgrdsrtqailplrgKilnvekarldrilnnneirqmitafgtgiggdfdlakaryhkivimtdadvdgahirtllltffyrfmrplieagyvyiaqpptgykglgemnadqlwettmnpehrallqvkledaieadqtfemlmgdvvenrrqfiednavynernitsemresfldYamsvivaRalpdvrdglkpvhrrilyglneqgmtpdksykksarivgdvmgkyhphgdSSiyeamvrmaqdfsyryplvdgqgnfgsmdgdgaaamRftearmtkitlellrdinkdtidfidnydgnerepsvlparfpnllangasgIavgmatnipphnltelingvlslsknpdisiaelmediegpdfptaglilgksgirrayetgrgsiqmrsravieergggrqrivvteipfqvnkarmiekiaelvrdkkidgitdlrdetslrtgvrvvidvrkdanasvilnnlykqtplqtsfgvnmialvngrpklinlkealvhylehqktvvrrrtqynlrkakdrahileglrialdhideiistiresdtdkvameslqqrfklsekqaqaildmrlrrltglerdkieaeynellnyiseletiladeevllqlvrdelteirdrfgddrrteiql
interface signature	KYRSSRI

Estimated binding specificities ?

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# IC=2.152 IC/col=0.113 n_of_columns=19

specificity:

A |  24  24  24  24  24  24  24  22  24  24  24  16  16  30   7   0  24  24  24
C |  24  24  24  24  24  24  24  25  24  24  24  45  19  22  74   0  24  24  24
G |  24  24  24  24  24  24  24  27  24  24  24  16  16  22   7  96  24  24  24
T |  24  24  24  24  24  24  24  22  24  24  24  19  45  22   8   0  24  24  24

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updated Mon Dec 18 20:11:55 2023