interface graph thumbnail
legend  pdf

structure name2.22A STRUCTURE OF THIOPHENE2 AND GSK945237 WITH S.AUREUS DNA GYRASE AND DNA
referenceStavenger et al. 'Proc. 114 E4492 2017
experimentX-ray (resolution=2.22, R-factor=0.184)
structural superfamilyType II DNA topoisomerase;
sequence familyDNA gyrase/topoisomerase IV, subunit A; DNA gyrase B subunit, carboxyl terminus; Toprim domain;
multimeric complexes2xcs_BD 4bul_AC 4plb_BD 5bs3_BD 5npk_bd 6fm4_BD 7mvs_AB
reference complex5npk_d
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRKYSI

Estimated binding specificities ?

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# IC=3.101 IC/col=0.620 n_of_columns=5 specificity:   
A |  16  13  24   0   0
C |  54  16  24  96   0
G |  13  13  24   0  96
T |  13  54  24   0   0
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updated Mon Dec 18 13:25:44 2023