5ego_B : 3D-footprint complex

structure name	HOXB13-MEIS1 HETERODIMER BOUND TO METHYLATED DNA (HOMEOBOX PROTEIN HOX-B13)
reference	Morgunova et al. Science 356 ? 2017
source	HOMO SAPIENS
experiment	X-ray (resolution=2.54, R-factor=0.230)
structural superfamily	Homeodomain-like;
sequence family	Homeobox domain;
multimeric complexes	5edn_AJ 5edn_BG 5eg0_AB 5ego_AB 5no6_AN 5no6_BI
redundant complexes	5eg0 5no6
reference complex	7psx_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5ego_B interface=1,4,46,49,50, RkkRipyskgqlrelereyaankfitkdkrrkisaatslserqitIwfQNrrvkekkvlakvk
interface signature	RRIQN

Estimated binding specificities ?

contact

# IC=3.443 IC/col=0.492 n_of_columns=7

specificity:

A |  10  12   0  96  24  24  45
C |  10  12   0   0  24  24  16
G |  13  12   0   0  24  24  19
T |  63  60  96   0  24  24  16

scan!

Dendrogram of similar interfaces ?

matrix format

  
  --RA--------------YAQTNAAARG   L                     +-----------6wig_A    
                                               +-------2 
  ----------------RTVAITNAMCRG   L             !       +-----------1yrn_A    
                                     +---------3 
  RCRT--------------NT--NAITRG   L   !         !            +------5zjt_B    
                                   --4         +------------1 
  ----------------RCVACTNAQA--   L   !                      +------7xrc_C    
                                     ! 
  --YTRTTGRGSTATEAST----------   L   +-----------------------------6xg8_A

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updated Mon Dec 18 12:38:25 2023