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structure nameCRYSTAL STRUCTURE OF ISCR BOUND TO ITS PROMOTER
(HTH-type transcriptional regulator IscR)
referenceRajagopalan et al. Nat.Struct.Mol.Biol. 20 740 2013
sourceEscherichia coli
experimentX-ray (resolution=2.22, R-factor=0.205)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyTranscriptional regulator;
multimeric complexes4chu_AB 4hf1_AB 4hf2_AB
redundant complexes4chu_A 4hf2_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSSYEQRP

Estimated binding specificities ?

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# IC=3.569 IC/col=0.714 n_of_columns=5 specificity:   
A |   0  77  24  20   0
C |   0   0  24  19   0
G |   0  19  24  38  96
T |  96   0  24  19   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ------ST--SAYTECQT------------RTPT----   L                                          +----4hf1_A    
                                                                     +----------------1 
  ----------TTHT--KG------------RC------   L                      +--4                +----7b0c_A    
                                                                  !  ! 
  RC------------------------------------                        +-5  +---------------------6l9z_S    
                                                                ! ! 
  --RA--ST--ECTTRAKA------------HT------                      +-6 +------------------------7oz3_B    
                                                              ! ! 
  ----------------RC--YG----KT----------                    +-7 +-------------------------2acj_B    
                                                            ! ! 
  ------------------------------------NG                  +-8 +--------------------------7k63_U    
                                                          ! ! 
  --RC--------------------------------SG                +-9 +---------------------------7cow_T    
                                                        ! ! 
  --ETNTSCRGHC--RT--------------QA------             +-10 +---------------------------5d4s_B    
                                                     !  !  
  ------STRGQTQAST------------HG----KT--   L      +-11  +---------------------------7t8k_B    
                                                  !  !  
  ------NTHG--RTYTPT--------------RT----   L      !  !             +--------------6qil_A    
                                               +-12  +-------------3 
  --------------NASTRTHT--ST------------       !  !                +--------------3co7_C    
                                               !  !  
  ----------KGTA--TA----RG--------------   L -13  +----------------------------1xsd_A    
                                               !  
  --------------------YGRG--------------       !                    +-------4wcg_A    
                                               +--------------------2 
  ------SGRGPT--SGRG--------------------   L                        +-------7bhy_A    
                                             

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updated Tue Dec 19 08:55:34 2023