2c7p_A : 3D-footprint complex

structure name	HHAI DNA METHYLTRANSFERASE COMPLEX WITH OLIGONUCLEOTIDE CONTAINING 2- AMINOPURINE OPPOSITE TO THE TARGET BASE (GCGC:GMPC) AND SAH (MODIFICATION METHYLASE HHAI)
reference	Klimasauskas et al. 'Nucleic 33 6953 2005
source	HAEMOPHILUS HAEMOLYTICUS
experiment	X-ray (resolution=1.70, R-factor=0.196)
structural superfamily	S-adenosyl-L-methionine-dependent methyltransferases;
sequence family	C5 cytosinespecific DNA methylase;
redundant complexes	2z6u 2uyc 2z6a 9mht 2uz4 2c7o 2uyh 2z6q 2hr1 4mht 1skm 6mht 1fjx 2i9k 2c7q 2c7r 1m0e 3mht 10mh 3eeo 5mht 7mht 2zcj 1mht 8mht
reference complex	5ciy_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 2c7p_A interface=81,86,87,119,120,121,163,165,228,237,240,252,254,260,261,304, mieikdkqltglrfidlfaglggfrlalescgaecvysnewdkyaqevyemnfgekpegditqvnektipdhdilcagfpCqafsISgkqkgfedsrgtlffdiarivrekkpkvvfmENVknfashdngntlevvkntmneldysfhakvlnaldygipqkReRiymicfrndlniqnfqfpkpfelntfvkdlllpdsevehlvidrkdlvmtnqeieqttpktvRlgivgkggQgeRiystrgiaitlSaYgggifAKtggylvngktrklhprecarvmgypdsykvhpstsqaykqfgNsvvinvlqyiaynigsslnfkpy
interface signature	CISENVRRRQRSYAKN

Estimated binding specificities ?

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# IC=4.632 IC/col=0.926 n_of_columns=5

specificity:

A |  20  74   0   0   0
C |  38   7   0  96   0
G |  19   7  96   0  96
T |  19   8   0   0   0

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Dendrogram of similar interfaces ?

matrix format

  
  --------------CC----ITSG------ECNCVCRCRCRA----QG--RGSGYC--ATKT--NC   L                          +----2c7p_A    
                                                                              +-------------------1 
  --------------------VGQG------------------FGNGSGEG------AGNG--RA--   L   +--2                   +----4dkj_A    
                                                                           !  ! 
  ----------NAFA----------------------------------------------------     --3  +------------------------2y7h_B    
                                                                           ! 
  FTDTITVTYTAT----KAAA----WGLGIT------------------------------------   L   +---------------------------3zh2_C

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updated Mon Dec 18 06:36:43 2023