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structure nameX-RAY STRUCTURE OF THE COMPLEX BETWEEN HUMAN ALPHA THROMBIN AND A THROMBIN BINDING APTAMER VARIANT (TBA-3LEU), WHICH CONTAINS LEUCYL AMIDE IN THE SIDE CHAIN OF THY3 AT N3.
(PROTHROMBIN)
referenceTimofeev et al. 'Mol 23 863 2021
sourceHOMO SAPIENS
experimentX-ray (resolution=2.53, R-factor=0.249)
structural superfamilyTrypsin-like serine proteases;
sequence familyTrypsin;
multimeric complexes1hap_HL 1hut_HL 4dih_HL 4dii_HL 4lz4_CD 6evv_HL 6gn7_HL 7zkl_HL
reference complex6z8v_H
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureIHRYRIY

Estimated binding specificities ?

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# IC=7.910 IC/col=0.719 n_of_columns=11 specificity:   
A |  14   0   0  24  24  24  24   2   0   0   0
C |  14   0   0  24  24  24  24   2   0   0   0
G |  52   0  96  24  24  24  24  90   0   0  96
T |  16  96   0  24  24  24  24   2  96  96   0
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updated Mon Dec 18 19:25:21 2023