interface graph thumbnail
legend  pdf

structure nameHUMAN APE1 E96Q/D210N MISMATCH SUBSTRATE COMPLEX
(DNA-apurinic or apyrimidinic site lyase)
referenceFreudenthal et al. Nat.Struct.Mol.Biol. 22 924 2015
sourceHomo sapiens
experimentX-ray (resolution=1.85, R-factor=0.161)
structural superfamilyDNase I-like;
sequence familyEndonuclease/Exonuclease/phosphatase fa;
reference complex5dff_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureDKYRNNYMMD

Estimated binding specificities ?

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# IC=1.772 IC/col=0.295 n_of_columns=6 specificity:   
A |  10  22   4  24   9  18
C |  63  25   4  24  69  18
G |  13  27   4  24   9  42
T |  10  22  84  24   9  18
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updated Mon Dec 18 12:29:57 2023