3qlp_H : 3D-footprint complex

structure name	X-RAY STRUCTURE OF THE COMPLEX BETWEEN HUMAN ALPHA THROMBIN AND A MODIFIED THROMBIN BINDING APTAMER (MTBA) (THROMBIN HEAVY CHAIN)
reference	Russo Krauss et al. 'Nucleic 39 7858 2011
source	HOMO SAPIENS
experiment	X-ray (resolution=2.14, R-factor=0.186)
structural superfamily	Trypsin-like serine proteases;
sequence family	Trypsin;
multimeric complexes	1hap_HL 1hut_HL 4dih_HL 4dii_HL 4lz4_CD 6evv_HL 6gn7_HL 7zkl_HL
redundant complexes	1hao 1hap 1hut
reference complex	6z8v_H
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 3qlp_H interface=9,24,60,66,70,71,73,74,75,78, ivegsdaeIgmspwqvmlfrkspQellcgaslisdrwvltaahcllyppwdknftendlLvrigkHsrtRYeRNIekIsmlekiyihprynwrenldrdialmklkkpvafsdyihpvclpdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstriritdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfythvfrlkkwiqkvidqfge
interface signature	IQLHRYRNII

Estimated binding specificities ?

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# IC=9.637 IC/col=0.741 n_of_columns=13

specificity:

A |   0   0   0   0  24  24  24  24  24   7   0   0   2
C |   0   0   0   0  24  24  24  24  24   7   0   0   2
G |  96   0   0  96  24  24  24  24  24  74   0   0  90
T |   0  96  96   0  24  24  24  24  24   8  96  96   2

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Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: ALPHA-THROMBIN
GGTTGGTGTGGTTGG	PubMed	3qlp_H(1.21e-05), 1hut_HL(2.91e-03), 1hao_H(4.44e-04)

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updated Mon Dec 18 08:52:17 2023