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structure nameCRYSTAL STRUCTURE OF A MUTANT OF THE LARGE FRAGMENT OF DNA POLYMERASE I FROM THERMUS AQUATICUS IN A CLOSED TERNARY COMPLEX WITH DNA AND DDCTP
(DNA polymerase I)
referenceDiederichs et al. Chembiochem 12 1574 2011
sourceThermus aquaticus
experimentX-ray (resolution=1.74, R-factor=0.171)
structural superfamilyDNA/RNA polymerases;Ribonuclease H-like;
sequence familyDNA polymerase family A; Taq polymerase, exonuclease;
redundant complexes3rrh 3m8s 4ktq 3t3f 3ojs 3lwm 3ktq 1qsy 3rrg 3m8r 1qss 3po5 1tau 3lwl 1qtm 3po4 3rr8 3rr7 2ktq 3oju
reference complex6fbc_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKTRNNTFYMQH

Estimated binding specificities ?

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# IC=3.412 IC/col=0.569 n_of_columns=6 specificity:   
A |   8  24  57   6   0  15
C |   6  24   6  83   0  57
G |  76  24  25   6  96  12
T |   6  24   8   1   0  12
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Dendrogram of similar interfaces ?

matrix format
  
  ----------------------KC----------RG--NGNGTGFG--YGMGSA----------QG--HG   L                         +-3py8_A    
                                                                                                   +-1 
  ----------------------KT----------RG--NGNTAAYA--YAIASTYTNARTFANAQA--HG   L                 +-----2 +-3pv8_D    
                                                                                             !     ! 
  LCNGKGYGMGRCEG------------SGHGVC--------------------------------------       +-------------3     +---1kln_A    
                                                                               !             ! 
  ------------------------KT--------RT--NG--------YA--------------QA----     --4             +---------1x9m_A    
                                                                               ! 
  --------------ATYTDGKG----------RCRCYC--------TTYT----------------HT--       +-----------------------1msw_D    
                                                                             

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updated Mon Dec 18 08:47:02 2023