3mx9_A : 3D-footprint complex

structure name	MOLECULAR BASIS OF ENGINEERED MEGANUCLEASE TARGETING OF THE ENDOGENOUS HUMAN RAG1 LOCUS (Protein scV3V2G19S)
reference	Subramanian et al. 'Nucleic 39 729 2011
source	Chlamydomonas reinhardtii
experiment	X-ray (resolution=2.60, R-factor=0.184)
structural superfamily	Homing endonucleases;
sequence family	LAGLIDADG endonuclease;
reference complex	3mxa_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 3mx9_A interface=21,23,25,31,37,39,43,45,65,67,72,74,167,169,171,173,175,177,178,183,189,191,213,215,218,220,222,224,285, ntkynkefllylagfvdgdgSiIaQinpnqSskfkhRlRltfYvTqktqrrwfldklvdeigvgYvRdsgsVsQyvlseikplhnfltqlqpflklkqkqanlvlkiieqlpsakespdkflevctwvdqiaalndsktrkttsetvrasnkefllylagfvdsdgSiIaQiKpRqSNkfkhQlsltfAvTqktqrrwfldklvdeigvgyvYdSgsVsDyRlSeikplhnfltqlqpflklkqkqanlvlkiieqlpsakespdkflevctwvdqiaalndskTrkttsetvravld
interface signature	SIQSRRYTYRVQSIQKRSNQATYSVDRST

Estimated binding specificities ?

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# IC=23.908 IC/col=0.996 n_of_columns=24

specificity:

A |   2  24   2   0   0  13   0   0  96   5   8   2  90  24   5   0   0  96   0  24  84   0  96  92
C |   0  24   0   0   0  79   0   0   0   4   8   2   2  24  74   0   0   0   0  24   5  96   0   2
G |   0  24   0  96  96   2   0  96   0  82  74   5   2  24   8   0  96   0  96  24   2   0   0   2
T |  94  24  94   0   0   2  96   0   0   5   6  87   2  24   9  96   0   0   0  24   5   0   0   0

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Dendrogram of similar interfaces ?

matrix format

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updated Mon Dec 18 08:33:55 2023