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legend  pdf

structure nameCRYSTAL STRUCTURE OF FOXO1 DBD BOUND TO IRE DNA
(Forkhead box protein O1)
referenceMarmorstein et al. Structure 16 1407 2008
sourceHomo sapiens
experimentX-ray (resolution=2.20, R-factor=?)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyFork head domain;
multimeric complexes6lbi_CD 6lbi_GH 6lbi_KL
redundant complexes3co7_F 6lbi_G
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNSRH

Estimated binding specificities ?

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# IC=5.123 IC/col=0.854 n_of_columns=6 specificity:   
A |  61  96  96  87   0  61
C |   8   0   0   0  78   8
G |  17   0   0   8   8  19
T |  10   0   0   1  10   8
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Dendrogram of similar interfaces ?

matrix format
  
  ------------NASA--RGHT--STLT--   L                                 +3coa_F    
                                                             +-------1 
  ------------NAST--RTHT--STLT--   L            +------------2       +4lg0_A    
                                                !            ! 
  --LTNTHGRT--YTPT--------------   L         +--3            +--------6qil_A    
                                             !  ! 
  ------------NA----RAHT--STLT--   L       +-4  +---------------------2a07_J    
                                           ! ! 
  --------------RC----YG------KT         +-5 +------------------------2acj_B    
                                         ! ! 
  ------------TTNT--RTCT--RAST--   L   +-6 +-------------------------2o61_A    
                                       ! ! 
  --------KT----RG----RGYA------     --7 +---------------------------1hbx_G    
                                       ! 
  DT------RGTT----KT------------   L   +---------------------------2o8k_A    
                                     

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updated Thu Dec 22 18:51:33 2022