DNA Binding Motif

						

			
Accessions: 2f8x_C (3D-footprint 20231221)

			
Names: Recombining binding protein suppressor of hairless, isoform 4
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of activated Notch, CSL and MAML on HES-1 promoter DNA sequence
Length: 8
Consensus: TTCCCACA
Weblogo: 
PSSM: P0      A      C      G      T
01      5      5      6     80      T
02      0      0      0     96      T
03      5     80      6      5      C
04      5     81      5      5      C
05      5     81      5      5      C
06     96      0      0      0      A
07      6     80      5      5      C
08     81      5      5      5      A
Binding TFs: 2f8x_C (IPT/TIG domain, Beta-trefoil DNA-binding domain, LAG1, DNA binding)
Binding Sites: 2f8x_X
2f8x_Y
			
Publications: Nam Y, Sliz P, Song L, Aster J.C, Blacklow S.C. Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell 124:973-83 (2006). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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