DNA Binding Motif

Accessions: 5und_AB (3D-footprint 20231221)
Names: Transcriptional repressor CTCF
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal Structure of CTCF(ZnF 4-10) With 28-mer DNA
Length: 25
Consensus: CCAGCAGGGGGCGcGcCCCCTGCTG
Weblogo:
PSSM: P0 A C G T
01 12 75 3 6 C
02 0 96 0 0 C
03 96 0 0 0 A
04 3 5 85 3 G
05 0 96 0 0 C
06 96 0 0 0 A
07 0 0 96 0 G
08 0 0 96 0 G
09 0 0 96 0 G
10 0 0 96 0 G
11 0 0 96 0 G
12 0 96 0 0 C
13 10 11 72 3 G
14 11 65 10 10 c
15 0 0 96 0 G
16 11 65 10 10 c
17 0 96 0 0 C
18 3 92 0 1 C
19 0 96 0 0 C
20 0 96 0 0 C
21 0 0 0 96 T
22 0 0 96 0 G
23 0 82 4 10 C
24 0 0 0 96 T
25 0 0 96 0 G
Type: Heterodimer
Binding TFs: 5und_A (Zinc finger, C2H2 type, Zinc-finger double domain, C2H2-type zinc finger, C2H2-type zinc-finger domain)
5und_B (Zinc finger, C2H2 type, Zinc-finger double domain, C2H2-type zinc finger, C2H2-type zinc-finger domain)
Binding Sites: 5und_C
5und_D
5und_E
5und_F
Publications: Hashimoto H, Wang D, Horton JR, Zhang X, Corces VG, Cheng X. Structural Basis for the Versatile and Methylation-Dependent Binding of CTCF to DNA. Mol Cell 66:711-720 (2017). [Pubmed]

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