DNA Binding Motif

Accessions: 3nbn_AD (3D-footprint 20231221)
Names: Recombining binding protein suppressor of hairless
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of a dimer of Notch Transcription Complex trimers on HES1 DNA
Length: 30
Consensus: CTgTGGGAAnnnnnnnnnnnnnnnTTCnCA
Weblogo:
PSSM: P0 A C G T
01 6 81 6 3 C
02 0 3 4 89 T
03 10 10 65 11 g
04 0 0 0 96 T
05 0 0 96 0 G
06 6 6 78 6 G
07 0 0 96 0 G
08 96 0 0 0 A
09 87 6 3 0 A
10 24 24 24 24 n
11 24 24 24 24 n
12 24 24 24 24 n
13 24 24 24 24 n
14 24 24 24 24 n
15 24 24 24 24 n
16 24 24 24 24 n
17 24 24 24 24 n
18 24 24 24 24 n
19 24 24 24 24 n
20 24 24 24 24 n
21 24 24 24 24 n
22 24 24 24 24 n
23 24 24 24 24 n
24 24 24 24 24 n
25 10 3 8 75 T
26 0 0 0 96 T
27 0 96 0 0 C
28 24 24 24 24 n
29 3 92 1 0 C
30 85 3 5 3 A
Binding TFs: 3nbn_A / 3nbn_D (IPT/TIG domain, Beta-trefoil DNA-binding domain, LAG1, DNA binding)
Binding Sites: 3nbn_X
3nbn_Y
Publications: Arnett K.L, Hass M, McArthur D.G, Ilagan M.X, Aster J.C, Kopan R, Blacklow S.C. Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes. Nature structural & molecular biology 17:1312-7 (2010). [Pubmed]

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