DNA Binding Motif

Accessions: 5t7x_AB (3D-footprint 20231221)
Names: Epstein-Barr nuclear antigen 1
Organisms: Epstein-Barr virus (strain GD1) (HHV-4), Human herpesvirus 4
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of HHV-4 EBNA1 DNA binding domain (patient-derived, nasopharyngeal carcinoma) bound to DNA
Length: 18
Consensus: GGATAGCnnntGcTACCC
Weblogo:
PSSM: P0 A C G T
01 0 2 92 2 G
02 0 0 96 0 G
03 94 0 2 0 A
04 0 0 0 96 T
05 92 2 0 2 A
06 12 7 68 9 G
07 0 96 0 0 C
08 24 24 24 24 n
09 24 24 24 24 n
10 24 24 24 24 n
11 12 11 9 64 t
12 1 2 91 2 G
13 14 64 9 9 c
14 0 3 2 91 T
15 83 0 12 1 A
16 0 96 0 0 C
17 0 96 0 0 C
18 0 91 3 2 C
Type: Heterodimer
Binding TFs: 5t7x_A (Epstein Barr virus nuclear antigen-1, DNA-binding domain)
5t7x_B (Epstein Barr virus nuclear antigen-1, DNA-binding domain)
Binding Sites: 5t7x_C
5t7x_D
Publications: Dheekollu J, Malecka K, Wiedmer A, Delecluse HJ, Chiang AK, Altieri DC, Messick TE, Lieberman PM. Carcinoma-risk variant of EBNA1 deregulates Epstein-Barr Virus episomal latency. Oncotarget 8:7248-7264 (2017). [Pubmed]

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