7otx_CD : 3D-footprint complex

structure name	HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND INHIBITOR RMC-257
reference	Martinez et al. Eur.J.Med.Chem. 225 113785 2021
experiment	X-ray (resolution=3.45, R-factor=?)
structural superfamily	DNA/RNA polymerases;Ribonuclease H-like;
reference complex	7ozw_A 7ozw_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7otx_C interface=95,158,184,357,449, vpispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikkkdstkwrklvdfrelnkrtqdfwevqlgIphpaglkkkksvtvldvgdayfsvpldedfrkytaftipsinnetpgiryqynvlpqgwkgsPaifqssmtkilepfkkqnpdiviyqYmddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpivlpekdswtvndicklvgklnwasqiypgikvrqlskllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyaRmrgahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyqlekepivgaetfyvdgaanRetklgkagyvtnkgrqkvvpltnttnqktelqaiylalqdsglevnivtnsqyalgiiqaqpdkseselvnqiieqlikkekvylawvpahkgiggneqvdklvsa > 7otx_D interface= pietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikkkdstkwrklvdfrelnkrtqdfwevqlgiphpAglkkkksvtvldvgdayfsvpldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifQssmtkilepfkkqnpdiviyqymddLyvgsdleigqhrtkieelrqhllrwglwmgyelhpdkwtvqpivlpekdswtvndiqklvgklnwasqiypgikvrqlskllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqKittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyq
interface signature	IPYRR/AQLK

Estimated binding specificities ?

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# IC=4.133 IC/col=0.258 n_of_columns=16

specificity:

A |   0   0  27  24  24  24  24  24  24  24  24  24  24  24   9  96
C |   0   0  34  24  24  24  24  24  24  24  24  24  24  24  27   0
G |  96  90  13  24  24  24  24  24  24  24  24  24  24  24  54   0
T |   0   6  22  24  24  24  24  24  24  24  24  24  24  24   6   0

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updated Sun Dec 17 09:54:49 2023