interface graph thumbnail
legend  pdf

structure nameLYSINE ACETYLATED AND TYROSINE PHOSPHORYLATED STAT3 IN A COMPLEX WITH DNA
(Signal transducer and activator of transcription 3)
referenceZarivach et al. 'Biochim 1863 1343 2019
sourceHomo sapiens
experimentX-ray (resolution=2.85, R-factor=0.297)
structural superfamilyp53-like transcription factors;STAT;SH2 domain;
sequence familySTAT protein, DNA binding domain; STAT protein, allalpha domain; SH2 domain;
multimeric complexes6qhd_AB
reference complex1bg1_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKSNIQ

Estimated binding specificities ?

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# IC=2.635 IC/col=0.659 n_of_columns=4 specificity:   
A |   9   0  11   9
C |  11   0  67  67
G |   9   0   9   9
T |  67  96   9  11
scan!

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updated Mon Dec 18 17:37:32 2023