6an8_CD : 3D-footprint complex

structure name	STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 8.0
reference	Martinez et al. 'Protein 28 587 2019
experiment	X-ray (resolution=2.60, R-factor=?)
structural superfamily	DNA/RNA polymerases;Ribonuclease H-like;
reference complex	5d3g_B 7ozw_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6an8_C interface=96,185,267,450,477, mvpispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfackkkdstkwrklvdfrelnkrtqdfwevqlgIphpaglkkkksvtvldvgdayfsvpldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdiviyqYmddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpivlpekdswtvndiqklvgklNwasqiypgikvrqlskllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyqlekepivgaetfyvdgaanRetklgkagyvtnkgrqkvvpltnttnQktelqaiylalqdsglevnivtdsqyalgiiqaqpdkseselvnqiieqlikkekvylawvpahkgiggneqvdklvs > 6an8_D interface= pietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaGlkkkksvtvldvgdayfsvpldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdiviyqymddlYvgsdleigqhrtkieelrqhllrwgyelhpdkwtvqpivlpekdswtvndiqklvgklnwasqiypgikvrqlskllrgtkAlteviplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyartndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyq
interface signature	IYNRQ/GYA

Estimated binding specificities ?

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# IC=2.295 IC/col=0.143 n_of_columns=16

specificity:

A |   7   7  24  24  24  24  24  24  24  24  24  24  24  24   9   9
C |   7  73  24  24  24  24  24  24  24  24  24  24  24  24  73  73
G |   7   7  24  24  24  24  24  24  24  24  24  24  24  24   7   7
T |  75   9  24  24  24  24  24  24  24  24  24  24  24  24   7   7

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updated Sat Dec 16 08:12:11 2023