interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF CTCF ZFS4-8-ECBS
(Transcriptional repressor CTCF)
referenceWang et al. 'Cell 27 1365 2017
sourceHomo sapiens
experimentX-ray (resolution=2.33, R-factor=0.224)
structural superfamilybeta-beta-alpha zinc fingers;
sequence familyZinc finger, C2H2 type;
reference complex5k5i_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureERRDYKRTQTRSD

Estimated binding specificities ?

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# IC=12.437 IC/col=0.957 n_of_columns=13 specificity:   
A |   5   0   2   5   7  96   0  90  11   0  24   0   5
C |  73  96   5  75   5   0   0   0   1   0  24  96   5
G |   7   0  84  11   5   0  96   6  84  96  24   0  86
T |  11   0   5   5  79   0   0   0   0   0  24   0   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  TTSC--EC--RGYGECSCKGRGDG--YCKGRG--TCQA----TC----   L     +-----------------------------5t0u_A    
                                                           ! 
  WT--AAHT--YA----QARAVTTT----NA------ECYTSGST--KG   L     !                      +------6wmi_A    
                                                           !                  +---1 
  --AG--KG--RG--RGDCKG------YC--------RGSTDCHG--RG   L   +-5           +------2   +------7eyi_G    
                                                         ! !           !      ! 
  ------------------YG--WT--WTSTET----FTVASGDCSART   L   ! !      +----3      +----------6a57_A    
                                                         ! !      !    ! 
  ----TTSGRTRG--LTECYC--NTYGQGFT------------------   L --6 +------4    +-----------------2lt7_A    
                                                         !        ! 
  ----------------SA----TT----NAVTRT--------------       !        +----------------------7y3m_I    
                                                         ! 
  ------------------------------------RG--SGDC----   L   +-----------------------------5k5l_F    
                                                       

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updated Mon Dec 18 14:07:54 2023