interface graph thumbnail
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structure nameCRYSTAL STRUCTURE OF FOXA2 DNA BINDING DOMAIN BOUND TO A FULL CONSENSUS DNA SITE
(Hepatocyte nuclear factor 3-beta)
referenceJiang et al. Biochemistry 56 3745 2017
sourceHomo sapiens
experimentX-ray (resolution=2.80, R-factor=0.243)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyFork head domain;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureN

Estimated binding specificities ?

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# IC=5.379 IC/col=0.896 n_of_columns=6 specificity:   
A |   0  96  96  69   9  69
C |   0   0   0   9  67   9
G |   0   0   0   9   9   9
T |  96   0   0   9  11   9
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: FOXA2
GTAAACAPubMed5x07_F(8.43e-10)

Dendrogram of similar interfaces ?

matrix format
  
  ------------------------NASTRGHT--STLT------------------   L                                                                +7cby_C    
                                                                                                                          +---2 
  ----------YC--KTHGSTQT--YTPT----------------------LG----   L                                          +-----------------6   +5x11_A    
                                                                                                        !                 ! 
  ------------------------NASTRGHT--STLT--------------KA--   L                                    +----12                 +----2c6y_A    
                                                                                                  !     !  
  ------------------------NASTRGHT--STFT------------------   L                                    !     +----------------------1vtn_C    
                                                                                                  !  
  ------------------------NASTRGHT--ST--------------------   L                                    !                              +3g73_A    
                                                                                                  !                    +---------1 
  ------------------------NA--RAHT--STLT------------------   L                                    !               +----8         +2a07_J    
                                                                                                  !               !    ! 
  --------------------------NTRGCT--NGST------------------   L                                 +-15      +--------9    +---------1if1_B    
                                                                                               !  !      !        ! 
  ------------ST----------NASTRTHT--ST--------------------   L                                 !  !      !        +--------------3l2c_A    
                                                                                               !  !   +-13  
  ------------------------------YG------------------------                                     !  !   !  !                      +4lb5_B    
                                                                                               !  !   !  !      +---------------3 
  ----KAFA--------------------------------------YANAKTFGMC                                     !  !   !  +-----11               +3aaf_B    
                                                                                               !  !   !         !  
  --------TT--------KATT--QTTG--LTRT----KA----------------   L                                 !  !   !         +----------------2p7c_B    
                                                                                               !  +--14  
  ------------------------NASTRTHT--STLT------------------   L                              +-16      !                    +---4lg0_A    
                                                                                            !  !      !                 +--4 
  ------------------------NGSARGHG--SC--------------------   L                              !  !      !        +--------7  +---6el8_A    
                                                                                            !  !      !        !        ! 
  ----------LTNTHG--RT--YTPT--------------------------RT--   L                              !  !      +-------10        +------6qil_A    
                                                                                            !  !               !  
  ------------------------NASTRGHT--ST--------------------   L                           +-17  !               !           +---6nce_A    
                                                                                         !  !  !               +-----------5 
  --RT------LT--NTHGTA----YTRG----------------------------                               !  !  !                           +---2efw_A    
                                                                                         !  !  !  
  ------------TT--RG----ST----------------------------KT--   L                        +-18  !  +----------------------------2qby_A    
                                                                                      !  !  !  
  ----------------------------------------KGKG------------   L                        !  !  +-----------------------------5xfr_B    
                                                                                   +-19  !  
  ----------------------------RGHT--ST--------------------   L                     !  !  +-----------------------------6akp_C    
                                                                                +-20  !  
  --------------------------------------------RA----------                      !  !  +-----------------------------7jgs_C    
                                                                             +-21  !  
  --------------------------------------------TGAGYGAT----                   !  !  +-----------------------------2wwy_B    
                                                                          +-22  !  
  ------------------------RGYC----------------------------                !  !  +-----------------------------5zmn_A    
                                                                       +-23  !  
  --------------------------YC----------------------------             !  !  +-----------------------------5zmo_A    
                                                                    +-24  !  
  PG------------------------------------------------------          !  !  +-----------------------------6la8_S    
                                                                 +-25  !  
  ----------------RGSTRT--STHG------------------------RA--   L   !  !  +-----------------------------3zpl_B    
                                                               -26  !  
  ------------STKTPTTT--FT----------------------------RA--   L   !  +-----------------------------4aso_F    
                                                                 !  
  ----------------RC--------YC----------------------------   L   +-----------------------------7cc9_A    
                                                               

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updated Thu Dec 22 22:27:49 2022