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structure nameCTCF ZNF2-7 AND DNA COMPLEX STRUCTURE
(Transcriptional repressor CTCF)
referenceHashimoto et al. 'Mol. 66 711 2017
sourceHomo sapiens
experimentX-ray (resolution=3.20, R-factor=0.231)
structural superfamilybeta-beta-alpha zinc fingers;
sequence familyZinc finger, C2H2 type;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureTTLTSERYESKRDYKRTQTRSD

Estimated binding specificities ?

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# IC=15.676 IC/col=1.045 n_of_columns=15 specificity:   
A |  64  24   8   0   0   0   0   0   0   0   0   0  16   0   0
C |   8  24  16  96   0  96  96  96  96  96   0   0  80   8   0
G |  16  24  16   0  96   0   0   0   0   0   0  96   0   8  96
T |   8  24  56   0   0   0   0   0   0   0  96   0   0  80   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --TTTCLA--------TTSC--EC--RGYG--EC--SCKGRG--DG--YCKG--RGTCQA----TC------RASCDC--   L                               +--5t0u_A    
                                                                                                               +-----2 
  ----SGHG--RG--RGDC--SCHG--------DC--SANA----WC--SCVG--RG--DC--SGNA--------STHGRG   L              +----------5     +--5v3g_A    
                                                                                                    !          ! 
  --------------------------------EC--SGKGRG--DG--YCKG--RG--QA----TC------RASCDCVT   L            +-8          +--------5k5h_A    
                                                                                                  ! ! 
  --------RG--YG--EC--SCKG--RG------TCYCKARGTCQAST--TC------RC--SCDC--VT----------   L            ! !           +-------5yef_B    
                                                                                                +-9 +-----------4 
  --------------------------------DC--YCKGRG--QA----TC------RC--SCDC--VT----------   L          ! !             +-------5k5i_A    
                                                                                                ! ! 
  ----------------DC--SCQG--KT--TTAT--SCSC----DC--SGATRARG--RG--DCNA--------------   L          ! +---------------------6ml4_A    
                                                                                             +-10  
  --ECSCKG--RG----DCTCYCKG--RG----QA----TC----RC--SCDC--VT------------------------   L       !  !         +-------------5und_A    
                                                                                             !  !      +--6 
  ------------------------------FT----KAYT----WT--WTST--ET--FTVASGDCSARG----------   L       !  !      !  !         +---6jnm_A    
                                                                                             !  +------7  +---------3 
  ------------------------------NGKT--WTKG--------HTHG--RGTGTT--ACNA--KGRG--------   L   +--11         !            +---1tf3_A    
                                                                                         !   !         ! 
  --------------------------------------YG----WT--WTST--ET--FTVASGDCSART----------   L   !   !         +----------------6a57_A    
                                                                                         !   !  
  RGSTYGYC--------QC--TGSTRAYT----------------------------------------------------   L -12   !                       +3uk3_C    
                                                                                         !   +-----------------------1 
  --------------------------------------------NT--STNA--VT--QTSTSGKG--RG----------   L   !                           +6u9q_A    
                                                                                         !  
  ------------------------------------TCSGRG--LT--ETYC------NTYGQG----------------   L   +---------------------------6dfb_A    
                                                                                       

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updated Thu Dec 22 22:03:23 2022