interface graph thumbnail
legend  pdf

structure nameSTRUCTURE OF A PHOP-DNA COMPLEX
(Response regulator)
reference'Sci 6 24442 2016
sourceMycobacterium tuberculosis
experimentX-ray (resolution=2.40, R-factor=0.185)
structural superfamilyCheY-like;C-terminal effector domain of the bipartite response regulators;
sequence familyResponse regulator receiver domain; Transcriptional regulatory protein, C te;
multimeric complexes5ed4_AB 5ed4_EF
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNVESYSYR

Estimated binding specificities ?

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# IC=7.625 IC/col=0.953 n_of_columns=8 specificity:   
A |   7   0  73   0  96   0   7   9
C |   7  96   9  96   0   0  75   7
G |   9   0   7   0   0  96   7   7
T |  73   0   7   0   0   0   7  73
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: PHOP
TCACAGCPubMed5ed4_A(1.29e-11), 5ed4_AB(1.68e-03), 5ed4_EF(1.93e-05)

Dendrogram of similar interfaces ?

matrix format
  
  ----------NTVCECSTYTSTYC--RA----   L                  +------------------5ed4_A    
                                                  +-----3 
  ----------RG--DTVT--STRG--WT----   L            !     !   +--------------6lxn_A    
                                                  !     +---2 
  ----------------RC--YG--KT------             +--4         +--------------2acj_B    
                                               !  ! 
  --------------------YGRG--------             !  !                    +---4wcg_A    
                                             +-5  +--------------------1 
  --------RC--------------------SG           ! !                       +---7cow_T    
                                           +-6 ! 
  ------RC------------------------         ! ! +---------------------------6l9z_S    
                                         +-7 ! 
  --TA----------------------------       ! ! +----------------------------4p0p_A    
                                       --8 ! 
  ----QA----------------------NG--       ! +----------------------------7k63_U    
                                         ! 
  ET------------------------------       +----------------------------7aud_E    
                                       

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updated Tue Dec 19 10:18:11 2023