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structure nameCRYSTAL STRUCTURE OF THE DNA BINDING DOMAIN OF HUMAN TRANSCRIPTION FACTOR FLI1 IN COMPLEX WITH A 10-MER DNA ACCGGAAGTG
(Friend leukemia integration 1 transcription factor)
referenceTsodikov et al. Biochemistry 54 7365 2015
sourceHomo sapiens
experimentX-ray (resolution=3.45, R-factor=0.225)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyEtsdomain;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKRY

Estimated binding specificities ?

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# IC=5.339 IC/col=0.890 n_of_columns=6 specificity:   
A |   9   0   0  96  67   9
C |  69   0   0   0   9  11
G |   9  96  96   0   9  67
T |   9   0   0   0  11   9
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Dendrogram of similar interfaces ?

matrix format
  
  ----------DCKT--RG----RGYA----KA   L                                     +5jvt_A    
                                                       +-------------------2 
  ------------KT--RG----RAYA------   L              +--7                   +6vge_A    
                                                    !  ! 
  --RC----------------------------                  !  +--------------------7cow_T    
                                                    ! 
  ------------KT--RG----RGYA------   L              !          +-------------4l18_B    
                                                  +-9     +----5 
  ----------------TT----CT--NGKG--   L            ! !     !    +-------------7oot_B    
                                                  ! ! +---6 
  ----------EC----RG----RGYC------   L            ! ! !   !                  +2stw_A    
                                               +-10 +-8   +------------------1 
  ------------KT--RG----RGYA------   L         !  !   !                      +3wts_C    
                                               !  !   ! 
  ----------------TT----CT--NGKG--   L         !  !   +----------------------7rh2_B    
                                            +-11  !  
  RC------------------------------          !  !  +-------------------------6l9z_S    
                                            !  !  
  ------------KT--RGAT--RGYA------   L      !  !                    +-----1bc8_C    
                                         +-12  +--------------------3 
  ------------------NT--CT--NGST--   L   !  !                       +-----1if1_B    
                                         !  !  
  ----LTNTHG--RTYTPT--------------   L -13  !                 +----------6qil_A    
                                         !  +-----------------4 
  --------------NAST--RGHT--STLT--   L   !                    +----------7cby_C    
                                         !  
  ----------DCKT--RG----RGYA------   L   +-----------------------------7jsa_J    
                                       

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updated Thu Dec 22 21:23:24 2022