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structure nameEXPANDING LAGALIDADG ENDONUCLEASE SCAFFOLD DIVERSITY BY RAPIDLY SURVEYING EVOLUTIONARY SEQUENCE SPACE
(Intron-encoded DNA endonuclease I-HjeMI)
referenceScharenberg et al. 'Nucleic 40 4954 2012
sourceTrichoderma reesei
experimentX-ray (resolution=3.00, R-factor=0.285)
structural superfamilyHoming endonucleases;
sequence familyLAGLIDADG endonuclease;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureYSTKYTEERRMRRCSYLNYISDAYTCRKTR

Estimated binding specificities ?

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# IC=18.716 IC/col=0.891 n_of_columns=21 specificity:   
A |   0   3  76  65   7  96   0  96  24  24  24  32   0   0   0   0   0   0  36  74   5
C |   0   2  10   7  88   0   0   0  24  24  24  25  96  96   0  96  96   0  60   7   7
G |   0   3   1  15   0   0  96   0  24  24  24  36   0   0   0   0   0   0   0   5  82
T |  96  88   9   9   1   0   0   0  24  24  24   3   0   0  96   0   0  96   0  10   2
scan!

Dendrogram of similar interfaces ?

matrix format

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updated Tue Dec 19 08:18:59 2023