3q06_ABCD : 3D-footprint complex

structure name	AN INDUCED FIT MECHANISM REGULATES P53 DNA BINDING KINETICS TO CONFER SEQUENCE SPECIFICITY
reference	Halazonetis et al. 'Embo 30 2167 2011
source	HOMO SAPIENS
experiment	X-ray (resolution=3.20, R-factor=?)
structural superfamily	p53-like transcription factors;p53 tetramerization domain;
reference complex	3q05_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 3q06_A interface=182,185, svpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnrrpilviitledssgnllgrdsfevrvcaCpgRdrrteeenlrkkktmdgeyftlqirgrerfeqfrernealelkdaq > 3q06_B interface=25,181,182,185, svpsqktyqgsygfrlgflhsgtaKsvtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnrrpilviitledssgnllgrdsfevrvcACpgRdrrteeenlrkkktmdgeyftlqirgrerfeqfrernealelkdaq > 3q06_C interface=25,182,185, svpsqktyqgsygfrlgflhsgtaKsvtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnrrpilviitledssgnllgrdsfevrvcaCpgRdrrteeenlrkkktmdgeyftlqirgrerfeqfrernealelkdaq > 3q06_D interface=181,182,185, svpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnrrpilviitledssgnllgrdsfevrvcACpgRdrrteeenlrkkktmdgeyftlqirgrerfeqfrernealelkdaq
interface signature	CR/KACR/KCR/ACR

Estimated binding specificities ?

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# IC=13.912 IC/col=0.927 n_of_columns=15

specificity:

A |   0  88   2   0   2   0   1  16  24  58   0  88   4   0   4
C |  96   2   2   0  88  96  79   4  24  13  96   2   2   0  11
G |   0   4   4  96   4   0   9  74  24  18   0   4   2  96   7
T |   0   2  88   0   2   0   7   2  24   7   0   2  88   0  74

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updated Fri Dec 15 16:23:51 2023