3q05_ABCD : 3D-footprint complex

structure name	AN INDUCED FIT MECHANISM REGULATES P53 DNA BINDING KINETICS TO CONFER SEQUENCE SPECIFICITY
reference	Halazonetis et al. 'Embo 30 2167 2011
source	HOMO SAPIENS
experiment	X-ray (resolution=2.40, R-factor=?)
structural superfamily	p53-like transcription factors;p53 tetramerization domain;
reference complex	3q05_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 3q05_A interface=155,183,184,187, sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnRrpilviitledssgnllgrdsfevrvcACpgRdrrteeenlrkktmdgeyftlqirgrerfeqfrernealelkdaqat > 3q05_B interface=27,155,183,184,187, sssvpsqktyqgsygfrlgflhsgtaKsvtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnRrpilviitledssgnllgrdsfevrvcACpgRdrrteeenlrkktmdgeyftlqirgrerfeqfrernealelkdaqat > 3q05_C interface=27,155,183,184,187, sssvpsqktyqgsygfrlgflhsgtaKsvtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnRrpilviitledssgnllgrdsfevrvcACpgRdrrteeenlrkktmdgeyftlqirgrerfeqfrernealelkdaqat > 3q05_D interface=155,183,184,187, sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfvqlaktvpvqlyvdstpppgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhsvvvpyeppevgsdyttiyfkfmcnsscmggmnRrpilviitledssgnllgrdsfevrvcACpgRdrrteeenlrkktmdgeyftlqirgrerfeqfrernealelkdaqat
interface signature	RACR/KRACR/KRACR/RACR

Estimated binding specificities ?

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# IC=11.294 IC/col=0.807 n_of_columns=14

specificity:

A |   0  84   0   0  11  24  24  24   0  67   0  84   0   0
C |  96   5   5   0  75  24  24  24   0  11  96   5   5   0
G |   0   5   5  96   5  24  24  24  96   7   0   5   7  96
T |   0   2  86   0   5  24  24  24   0  11   0   2  84   0

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updated Fri Dec 15 16:23:11 2023