| structure name | CRYSTAL STRUCTURE OF THE HUMAN FOXO3A-DBD BOUND TO DNA (FORKHEAD BOX PROTEIN O3A) |
| reference | Huang et al. 'Nucleic 35 6984 2007 |
| source | HOMO SAPIENS |
| experiment | X-ray (resolution=2.70, R-factor=0.242) |
| structural superfamily | "Winged helix" DNA-binding domain; |
| sequence family | Fork head domain; |
| links to other resources | NAKB  PDIdb DNAproDB |
| protein sequence | |
| interface signature | NSRHSR |
Estimated binding specificities ?
readout + contact |  |
A | 4 78 96 38 7 56 C | 2 6 0 19 75 13 G | 2 6 0 19 7 14 T | 88 6 0 20 7 13scan! |
Related DNA sequences reported in the literature ?
| site | source | matches (E-value) |
|---|---|---|
| term: FOXO3A | ||
| GTAAACA | PubMed | 2uzk_A(6.32e-06) |
| TTGTTTCA | PubMed | 2uzk_A(6.38e-03) |
Dendrogram of similar interfaces ?
matrix format--------------------NASTRGHT--ST----------------RT L +-----2uzk_A +------------1 --------------------NASTRTHT--ST------------------ +---4 +-----3co7_C ! ! --------------------NASTRGHTNTSTLT---------------- L +--7 +------------------7fj2_B ! ! --------------------NASTRGHT--STLT---------------- L ! +----------------------7cby_C +-8 ----------LTNTHG--RTYTPT-------------------------- L ! ! +-----------6qil_A ! ! +---------2 ----------LTNT--TA--YTRG----------------QA-------- ! +---5 +-----------2efw_A +--9 ! --------RC------------------------------------SG-- ! ! +---------------------7cow_T ! ! ----KAFA----------------------------YANAKTFGMC---- ! ! +-------------3aaf_B +-10 ! +--------3 ----------------------RC--YG------KT-------------- ! ! +--6 +-------------2acj_B ! ! ! --RC---------------------------------------------- +-11 ! +----------------------6l9z_S ! ! ! NC------------------TT--RGCT--NGKG---------------- L ! ! +----------------------------7rh2_B -12 ! ----------------------NTRGCT--NGST---------------- L ! +----------------------------1if1_B ! --------------------TT--RTCT--NGKG---------------- L +----------------------------7oot_B |
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updated Tue Dec 19 06:57:34 2023