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structure name1H, 13C AND 15N CHEMICAL SHIFT ASSIGNMENTS AND SOLUTION STRUCTURE FOR PARP-1 F1F2 DOMAINS IN COMPLEX WITH A DNA SINGLE-STRAND BREAK
(POLY ADP-RIBOSE POLYMERASE 1)
sourceHOMO SAPIENS
experimentNMR
structural superfamilyGlucocorticoid receptor-like DNA-binding domain;
sequence familyPolyADPribose polymerase and DNALigase Z;
multimeric complexes4av1_ABCD
redundant complexes4av1_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRSFVPRQLI

Estimated binding specificities ?

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# IC=5.614 IC/col=0.125 n_of_columns=45 specificity:   
A |   0  24  24  12  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  38  24  12  14   0  24  24  12  24  24  24  24  24  24  24  24  24  24  24  24  24  24  21   9  24   0
C |   0  24  24  12  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  19  24  60  14  96  24  24  12  24  24  24  24  24  24  24  24  24  24  24  24  24  24  33   9  24   0
G |  96  24  24  60  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  19  24  12  16   0  24  24  60  24  24  24  24  24  24  24  24  24  24  24  24  24  24  21  67  24  96
T |   0  24  24  12  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  20  24  12  52   0  24  24  12  24  24  24  24  24  24  24  24  24  24  24  24  24  24  21  11  24   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --RGSTFGVTPCRG--QCLCIG   L               +------------2n8a_A    
                                  +--------1 
  ------------RGKG--LCIG       +--2        +------------3odc_B    
                               !  ! 
  --RG--FCVGPG----------     --3  +---------------------3od8_G    
                               ! 
  STRG------------------       +------------------------4av1_A

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updated Tue Dec 19 06:43:02 2023