interface graph thumbnail
legend  pdf

structure nameHUMAN DNA TOPOISOMERASE I (70 KDA) IN COMPLEX WITH THE INDOLOCARBAZOLE SA315F AND COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
(DNA topoisomerase I)
referenceStaker et al. J.Med.Chem. 48 2336 2005
sourceHomo sapiens
experimentX-ray (resolution=3.00, R-factor=?)
structural superfamilyEukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment;DNA breaking-rejoining enzymes;Eukaryotic DNA topoisomerase I, dispensable insert domain;
sequence familyEukaryotic DNA topoisomerase I, DNA bind; Eukaryotic DNA topoisomerase I, catalyti;
reference complex1a31_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence

No structural evidence for specific binding to DNA (<4 informative columns)


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updated Mon Dec 18 06:03:11 2023