interface graph thumbnail
legend  pdf

structure nameHUMAN DNA TOPOISOMERASE I (70 KDA) IN COMPLEX WITH THE INDENOISOQUINOLINE MJ-II-38 AND COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
(DNA topoisomerase I)
referenceStaker et al. J.Med.Chem. 48 2336 2005
sourceHomo sapiens
experimentX-ray (resolution=3.00, R-factor=?)
structural superfamilyEukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment;DNA breaking-rejoining enzymes;Eukaryotic DNA topoisomerase I, dispensable insert domain;
sequence familyEukaryotic DNA topoisomerase I, DNA bind; Eukaryotic DNA topoisomerase I, catalyti;
reference complex1a31_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRIKYMNKDN

Estimated binding specificities ?

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# IC=2.714 IC/col=0.678 n_of_columns=4 specificity:   
A |  67   9   9   0
C |   9  69   9   0
G |   9   9   9   0
T |  11   9  69  96
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updated Mon Dec 18 06:03:00 2023