1rtd_AB : 3D-footprint complex

structure name	STRUCTURE OF A CATALYTIC COMPLEX OF HIV-1 REVERSE TRANSCRIPTASE: IMPLICATIONS FOR NUCLEOSIDE ANALOG DRUG RESISTANCE
reference	Harrison et al. Science 282 1669 1998
source	HUMAN IMMUNODEFICIENCY VIRUS 1
experiment	X-ray (resolution=3.20, R-factor=?)
structural superfamily	DNA/RNA polymerases;Ribonuclease H-like;
reference complex	1rtd_B 7ozw_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1rtd_A interface=61,74,94,115,157,183,184,258,448,475, kispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvFaikkkdstkwrkLvdfrelnkrtqdfwevqlgIphpaglkkkksvtvldvgdaYfsvpldedfrkytaftipsinnetpgiryqynvlpqgwkgsPaifqssmtkilepfrkqnpdiviyqYMddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpivlpekdswtvndiCklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyqlekepivgaetfyvdgaanRetklgkagyvtnkgrqkvvpltdttnQktqlqaiylalqdsglevnivtdsqyalgiiqaqpdeseselvnqiieqlikkekvylawvpahkgiggneqvdklvsa > 1rtd_B interface= spietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaIkkkdstkwrklvDfrelnkrtqdfwevqlgipHpaglkkkksvtvldvgdayfSvpldedfrkytaftipsinnetpgiryqynvlpqgwkgspaIfqssmtkilepfrkqnpdiviyqymDDlyvgsdleigqhrtkieelrqhllrwglttpgyelhpdkwtvqpivlpekdswtvndiqklvgklnwasqiypGikvrqlckllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyql
interface signature	FLIYPYMCRQ/IDHSIDDG

Estimated binding specificities ?

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# IC=6.292 IC/col=0.350 n_of_columns=18

specificity:

A |   7   0   0   7  24  24  24  24  24  24  24  24  24  24   7  24   0  73
C |  73  96   0   7  24  24  24  24  24  24  24  24  24  24   7  24   0   7
G |   9   0  96  73  24  24  24  24  24  24  24  24  24  24  75  24  96   9
T |   7   0   0   9  24  24  24  24  24  24  24  24  24  24   7  24   0   7

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updated Fri Dec 15 10:53:26 2023