interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE I DNA COMPLEX
(DNA TOPOISOMERASE I)
referenceChampoux et al. Biochemistry 39 6832 2000
sourceHomo sapiens
experimentX-ray (resolution=2.60, R-factor=?)
structural superfamilyEukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment;DNA breaking-rejoining enzymes;
sequence familyEukaryotic DNA topoisomerase I, DNA bind; Eukaryotic DNA topoisomerase I, catalyti;
reference complex1a31_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNRIYMNKDN

Estimated binding specificities ?

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# IC=4.759 IC/col=0.793 n_of_columns=6 specificity:   
A |   0  13   0  74  19   0
C |  96  17   0   8  17   0
G |   0  23  96  10  39   0
T |   0  43   0   4  21  96
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updated Mon Dec 18 05:03:17 2023