DNA Binding Motif

Accessions: 4yg7_BCDEGK (3D-footprint 20231221)
Names: Antitoxin HipB
Organisms: Escherichia coli, strain K12
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Structure of FL autorepression promoter complex
Length: 41
Consensus: TAnCCnnnnngGATAnnnnnnnnnnTAnnCCnnnnnGGGAT
Weblogo:
PSSM: P0 A C G T
01 0 0 0 96 T
02 96 0 0 0 A
03 24 24 24 24 n
04 3 91 2 0 C
05 4 81 7 4 C
06 24 24 24 24 n
07 24 24 24 24 n
08 24 24 24 24 n
09 24 24 24 24 n
10 24 24 24 24 n
11 9 11 60 16 g
12 2 2 88 4 G
13 94 0 0 2 A
14 0 0 0 96 T
15 96 0 0 0 A
16 24 24 24 24 n
17 24 24 24 24 n
18 24 24 24 24 n
19 24 24 24 24 n
20 24 24 24 24 n
21 24 24 24 24 n
22 24 24 24 24 n
23 24 24 24 24 n
24 24 24 24 24 n
25 24 24 24 24 n
26 2 4 4 86 T
27 96 0 0 0 A
28 24 24 24 24 n
29 24 24 24 24 n
30 0 96 0 0 C
31 9 69 7 11 C
32 24 24 24 24 n
33 24 24 24 24 n
34 24 24 24 24 n
35 24 24 24 24 n
36 24 24 24 24 n
37 0 0 96 0 G
38 2 4 88 2 G
39 0 0 96 0 G
40 96 0 0 0 A
41 2 4 4 86 T
Type: Heterodimer
Binding TFs: 4yg7_C / 4yg7_G (Helix-turn-helix, Helix-turn-helix domain, Cro/C1-type HTH DNA-binding domain, Helix-turn-helix domain, Helix-turn-helix domain)
4yg7_B / 4yg7_E (Helix-turn-helix, Helix-turn-helix domain, Cro/C1-type HTH DNA-binding domain, Helix-turn-helix domain, Helix-turn-helix domain)
Binding Sites: 4yg7_R
4yg7_T
Publications: Schumacher MA, Balani P, Min J, Chinnam NB, Hansen S, Vulić M, Lewis K, Brennan RG. HipBA-promoter structures reveal the basis of heritable multidrug tolerance. Nature 524:59-64 (2015). [Pubmed]

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