Transcription Factor
| Accessions: | NR4A1_HUMAN (HOCOMOCO 10), P22736 (JASPAR 2024) |
| Names: | Early response protein NAK1, NR4A1_HUMAN, Nuclear hormone receptor NUR/77, Nuclear receptor subfamily 4 group A member 1, Nur77, Orphan nuclear receptor HMR, Orphan nuclear receptor TR3, ST-59, Testicular receptor 3 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P22736 |
| Length: | 598 |
| Pfam Domains: | 266-334 Zinc finger, C4 type (two domains) 402-574 Ligand-binding domain of nuclear hormone receptor |
| Sequence: (in bold interface residues) | 1 MPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGY 60 61 TGEFDTFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQVYGCYPGPLSGPV 120 121 DEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSFGHFSPSQTYEGLRAWTEQLPKA 180 181 SGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHL 240 241 EGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAK 300 301 YICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDAS 360 361 PANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKW 420 421 AEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFG 480 481 DWIDSILAFSRSLHSLLVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVA 540 541 AVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF |
| Interface Residues: | 275, 276, 278, 279, 285, 286, 288, 289, 292, 293, 317, 343, 346, 348 |
| 3D-footprint Homologues: | 6fbq_A, 7wnh_D, 6l6q_B, 3g9m_B, 1a6y_A, 1lo1_A, 4oln_B, 8hbm_B, 5krb_G, 2han_B, 1kb2_B, 2a66_A, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_A, 1hcq_E, 3g6t_A, 1r4i_A, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B, 5emc_A, 7prw_B, 5cbx_B |
| Binding Motifs: | NR4A1_HUMAN.H10MO.C|M01396 rAAGGTCAs MA1112.1 waAAGGTCAc MA1112.2 kwAAAGGTCAva MA1112.3 AAAGGTCA |
| Binding Sites: | MA1112.3.13 / MA1112.3.14 / MA1112.3.15 / MA1112.3.16 MA1112.3.9 MA1112.3.1 / MA1112.3.7 MA1112.3.19 / MA1112.3.20 MA1112.1.1 MA1112.1.10 MA1112.1.11 MA1112.1.12 MA1112.1.13 MA1112.1.14 MA1112.1.15 MA1112.1.16 MA1112.1.17 MA1112.1.18 MA1112.1.19 MA1112.1.2 MA1112.1.20 MA1112.1.3 MA1112.1.4 MA1112.1.5 MA1112.1.6 MA1112.1.7 / MA1112.1.8 MA1112.1.9 MA1112.2.1 / MA1112.2.2 MA1112.2.10 / MA1112.2.13 MA1112.2.11 / MA1112.2.14 MA1112.2.12 / MA1112.2.15 MA1112.2.13 / MA1112.2.16 MA1112.2.14 / MA1112.2.17 MA1112.2.15 / MA1112.2.18 MA1112.2.16 / MA1112.2.19 MA1112.2.17 / MA1112.2.20 MA1112.2.18 MA1112.2.19 MA1112.2.2 / MA1112.2.5 MA1112.2.20 MA1112.2.3 / MA1112.2.6 MA1112.2.4 / MA1112.2.7 MA1112.2.5 / MA1112.2.8 MA1112.2.6 / MA1112.2.9 MA1112.2.10 / MA1112.2.7 MA1112.2.11 / MA1112.2.8 MA1112.2.9 MA1112.2.1 MA1112.2.12 MA1112.2.3 MA1112.2.4 MA1112.3.10 MA1112.3.11 MA1112.3.12 MA1112.3.17 / MA1112.3.18 MA1112.3.2 MA1112.3.3 MA1112.3.4 MA1112.3.5 MA1112.3.6 MA1112.3.8 |
| Publications: | Wansa KD, Harris JM, Muscat GE. The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment. J Biol Chem 277:33001-11 (2002). [Pubmed] |
| Related annotations: | PaperBLAST |
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