Transcription Factor
Accessions: | P54821 (JASPAR 2024) |
Names: | Homeobox protein PHOX1, Paired mesoderm homeobox protein 1, Paired-related homeobox protein 1, PRRX1_HUMAN, PRX-1 |
Organisms: | Homo sapiens |
Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
Uniprot: | P54821 |
Length: | 245 |
Pfam Domains: | 95-151 Homeobox domain 219-236 OAR domain |
Sequence: (in bold interface residues) | 1 MTSSYGHVLERQPALGGRLDSPGNLDTLQAKKNFSVSHLLDLEEAGDMVAAQADENVGEA 60 61 GRSLLESPGLTSGSDTPQQDNDQLNSEEKKKRKQRRNRTTFNSSQLQALERVFERTHYPD 120 121 AFVREDLARRVNLTEARVQVWFQNRRAKFRRNERAMLANKNASLLKSYSGDVTAVEQPIV 180 181 PRPAPRPTDYLSWGTASPYSAMATYSATCANNSPAQGINMANSIANLRLKAKEYSLQRNQ 240 241 VPTVN |
Interface Residues: | 35, 37, 38, 81, 94, 95, 96, 97, 98, 136, 137, 139, 140, 143, 144, 147, 148, 151 |
3D-footprint Homologues: | 7vwz_G, 5zfz_A, 4j19_B, 1ig7_A, 3d1n_M, 2h1k_B, 1puf_A, 1fjl_B, 6a8r_A, 3cmy_A, 1nk2_P, 1zq3_P, 1jgg_B, 6m3d_C, 3lnq_A, 2lkx_A, 7q3o_C, 6es3_K, 2ld5_A, 5jlw_D, 3rkq_B, 2r5y_A, 4xrs_G, 2hos_A, 4cyc_A, 1au7_A, 5flv_I, 3l1p_A, 3a01_E, 2h8r_B, 7psx_B, 1b72_A, 5hod_A, 1puf_B, 1ic8_B, 2hdd_A, 1e3o_C, 2xsd_C, 7xrc_C, 1le8_A, 1du0_A, 1o4x_A, 5zjt_E, 8g87_X, 4qtr_D |
Binding Motifs: | MA0716.1 yyAATTAr MA0716.2 yAATTA |
Publications: | Noyes M.B, Christensen R.G, Wakabayashi A, Stormo G.D, Brodsky M.H, Wolfe S.A. Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites. Cell 133:1277-89 (2008). [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.