Transcription Factor

Accessions: T104723_1.02 (CISBP 1.02), P13528 (JASPAR 2024)
Names: T104723_1.02;, unc-86, Transcription factor unc-86, UNC86_CAEEL, Uncoordinated protein 86
Organisms: Caenorhabditis elegans
Libraries: CISBP 1.02 1, JASPAR 2024 2
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: experiment type:PBM, family:Homeodomain,POU
Length: 467
Pfam Domains: 267-342 Pou domain - N-terminal to homeobox domain
364-420 Homeobox domain
Sequence:
(in bold interface residues)
1 MEKAHRFRLPFCSFFPVPLLVSVLIFHHSAPFLIQLFFPSPLFNPLLRPSKISRGSENGA 60
61 CTSHSTLQRTRKIIQWELPKRGGDQDIGDPRPFRIHLSPPSFKVPLFSTDMQNTAPVPTT 120
121 TTASKMQPFNNSLFGSFDDPILNARAAQVALADIDVKNVPQLTNPLMRPHDMFSYSNYFS 180
181 GIHDTSAATNIYQGLPSSSEPFDASVVVPTSSDDQMTPLQQVMAMQQSYGAPPPFQYNMT 240
241 HPFSTTSIASSNNLARYPIAPPTSDMDTDPRQLETFAEHFKQRRIKLGVTQADVGKALAH 300
301 LKMPGVGSLSQSTICRFESLTLSHNNMVALKPILHSWLEKAEEAMKQKDTIGDINGILPN 360
361 TDKKRKRTSIAAPEKRELEQFFKQQPRPSGERIASIADRLDLKKNVVRVWFCNQRQKQKR 420
421 DFRSQFRARSAAAVMGPRVMPVLNGNNSNNNLKQGQTTYNGLPGFFD
Interface Residues: 291, 310, 311, 312, 313, 315, 316, 322, 326, 364, 365, 366, 367, 368, 405, 406, 408, 409, 412, 413, 416, 417, 420
3D-footprint Homologues: 3d1n_M, 3l1p_A, 7u0g_M, 1o4x_A, 8g87_X, 2xsd_C, 1e3o_C, 1au7_A, 7xrc_C, 1puf_A, 6a8r_A, 2h1k_B, 1fjl_B, 3cmy_A, 1nk2_P, 1jgg_B, 3lnq_A, 2lkx_A, 5zfz_A, 1zq3_P, 7q3o_C, 2ld5_A, 6es3_K, 7psx_B, 5flv_I, 2hos_A, 5zjt_E, 5hod_A, 3a01_E, 1puf_B, 2hdd_A, 1b72_A, 2r5y_A, 5jlw_D, 1ig7_A, 1le8_A, 1du0_A, 4cyc_A, 2d5v_B, 4qtr_D, 4xrs_G, 3rkq_B
Binding Motifs: M1229_1.02 dTATGCAT
MA0926.1 dTATGCAT
Publications: Xue D., Finney M., Ruvkun G., Chalfie M. Regulation of the mec-3 gene by the C.elegans homeoproteins UNC-86 and MEC-3. EMBO J. 11:4969-4979 (1992). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.