Transcription Factor
| Accessions: | Q8NEA6 (JASPAR 2024) |
| Names: | GLI-similar 3, GLIS3_HUMAN, Zinc finger protein 515, Zinc finger protein GLIS3 |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q8NEA6 |
| Length: | 775 |
| Pfam Domains: | 346-370 C2H2-type zinc finger 399-425 Zinc-finger double domain 413-436 C2H2-type zinc finger 413-436 Zinc finger, C2H2 type 428-455 Zinc-finger double domain 442-466 C2H2-type zinc finger 472-496 C2H2-type zinc finger 472-496 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 MMVQRLGLISPPASQVSTACNQISPSLQRAMNAANLNIPPSDTRSLISRESLASTTLSLT 60 61 ESQSASSMKQEWSQGYRALPSLSNHGSQNGLDLGDLLSLPPGTSMSSNSVSNSLPSYLFG 120 121 TESSHSPYPSPRHSSTRSHSARSKKRALSLSPLSDGIGIDFNTIIRTSPTSLVAYINGSR 180 181 ASPANLSPQPEVYGHFLGVRGSCIPQPRPVPGSQKGVLVAPGGLALPAYGEDGALEHERM 240 241 QQLEHGGLQPGLVNHMVVQHGLPGPDSQSAGLFKTERLEEFPGSTVDLPPAPPLPPLPPP 300 301 PGPPPPYHAHAHLHHPELGPHAQQLALPQATLDDDGEMDGIGGKHCCRWIDCSALYDQQE 360 361 ELVRHIEKVHIDQRKGEDFTCFWAGCPRRYKPFNARYKLLIHMRVHSGEKPNKCTFEGCE 420 421 KAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCT 480 481 KRYTDPSSLRKHVKAHSSKEQQARKKLRSSTELHPDLLTDCLTVQSLQPATSPRDAAAEG 540 541 TVGRSPGPGPDLYSAPIFSSNYSSRSGTAAGAVPPPHPVSHPSPGHNVQGSPHNPSSQLP 600 601 PLTAVDAGAERFAPSAPSPHHISPRRVPAPSSILQRTQPPYTQQPSGSHLKSYQPETNSS 660 661 FQPNGIHVHGFYGQLQKFCPPHYPDSQRIVPPVSSCSVVPSFEDCLVPTSMGQASFDVFH 720 721 RAFSTHSGITVYDLPSSSSSLFGESLRSGAEDATFLQISTVDRCPSQLSSVYTEG |
| Interface Residues: | 358, 360, 361, 364, 392, 393, 394, 395, 396, 397, 398, 399, 400, 401, 403, 404, 405, 407, 424, 425, 426, 427, 428, 430, 431, 454, 455, 456, 457, 458, 459, 460, 461, 462, 484, 485, 486, 487, 488, 489, 490, 491, 492, 510, 511, 512, 527, 529 |
| 3D-footprint Homologues: | 5yel_A, 2i13_A, 6blw_A, 6wmi_A, 6jnm_A, 7n5w_A, 3uk3_C, 8cuc_F, 2gli_A, 1tf6_A, 1ubd_C, 5ei9_F, 8ssu_A, 5v3j_F, 8h9h_G, 7eyi_G, 6e94_A, 6a57_A, 5k5i_A, 5kkq_D, 8ssq_A, 7w1m_H, 2jpa_A, 1tf3_A, 7y3l_A, 1g2f_F, 6u9q_A, 4x9j_A, 1llm_D, 5kl3_A, 2wbs_A, 7ysf_A, 1mey_C, 5und_A, 1f2i_J, 2kmk_A, 6ml4_A, 2lt7_A, 7y3m_I, 7txc_E, 5yj3_D, 2drp_D, 4m9v_C |
| Binding Motifs: | MA0737.1 KACCCCCCACgAAG |
| Publications: | Lichti-Kaiser K, ZeRuth G, Kang HS, Vasanth S, Jetten AM. Gli-similar proteins: their mechanisms of action, physiological functions, and roles in disease. Vitam Horm : (2012;88:141-71.). [Pubmed] |
| Related annotations: | PaperBLAST |
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