Transcription Factor
| Accessions: | Q5Q9J1 (JASPAR 2024), Q9S7Q7 (JASPAR 2024), T22931 (AthalianaCistrome v4_May2016) |
| Names: | At5g10140, FLC, Flowering locus C protein, Flowering time protein, Q5Q9J1_ARATH, FLC_ARATH, MADS-box protein FLOWERING LOCUS C, MADS-box protein FLOWERING LOCUS F, AGL25, T22931; |
| Organisms: | Arabidopsis thaliana |
| Libraries: | JASPAR 2024 1, AthalianaCistrome v4_May2016 2 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] 2 O'Malley RC, Huang SS, Song L, Lewsey MG, Bartlett A, Nery JR, Galli M, Gallavotti A, Ecker JR. Cistrome and Epicistrome Features Shape the Regulatory DNA Landscape. Cell 165:1280-92 (2016). [Pubmed] |
| Uniprot: | Q5Q9J1 |
| Notes: | ecotype:Col-0, experiment type: ampDAP-seq, experiment type: ampDAP-seq (methyl-cytosines removed by PCR), experiment type: DAP-seq, family:MADS |
| Length: | 196 |
| Pfam Domains: | 9-59 SRF-type transcription factor (DNA-binding and dimerisation domain) 84-165 K-box region |
| Sequence: (in bold interface residues) | 1 MGRKKLEIKRIENKSSRQVTFSKRRNGLIEKARQLSVLCDASVALLVVSASGKLYSFSSG 60 61 DNLVKILDRYGKQHADDLKALDHQSKALNYGSHYELLELVDSKLVGSNVKNVSIDALVQL 120 121 EEHLETALSVTRAKKTELMLKLVENLKEKEKMLKEENQVLASQMENNHHVGAEAEMEMSP 180 181 AGQISDNLPVTLPLLN |
| Interface Residues: | 3, 4, 15, 18, 19, 23 |
| 3D-footprint Homologues: | 1hbx_A, 1n6j_A, 1c7u_A, 7x1n_C, 1mnm_A |
| Binding Motifs: | MA0558.1 aawwwCymAAAAwrGAAAgww M0485 / MA1200.1 wcTTTCCwtwTttrgaaa M0486 cTTTCCwTTTTtRGa MA0558.2 CymAAAAwrGAAAg |
| Binding Sites: | MA0558.1.1 MA0558.1.10 MA0558.1.11 MA0558.1.12 MA0558.1.13 MA0558.1.14 MA0558.1.15 MA0558.1.16 MA0558.1.17 MA0558.1.18 MA0558.1.19 MA0558.1.2 MA0558.1.20 MA0558.1.3 MA0558.1.4 MA0558.1.5 MA0558.1.6 MA0558.1.7 MA0558.1.8 MA0558.1.9 MA0558.2.1 MA0558.2.10 MA0558.2.11 MA0558.2.12 MA0558.2.13 MA0558.2.14 MA0558.2.15 MA0558.2.16 MA0558.2.17 MA0558.2.18 MA0558.2.19 MA0558.2.2 MA0558.2.20 MA0558.2.3 MA0558.2.4 MA0558.2.5 MA0558.2.6 MA0558.2.7 MA0558.2.8 MA0558.2.9 |
| Publications: | Deng W, Ying H, Helliwell C.A, Taylor J.M, Peacock W.J, Dennis E.S. FLOWERING LOCUS C (FLC) regulates development pathways throughout the life cycle of Arabidopsis. Proceedings of the National Academy of Sciences of the United States of America 108:6680-5 (2011). [Pubmed] Tang W., Perry S. E. Binding site selection for the plant MADS domain protein AGL15: an in vitro and in vivo study.. J. Biol. Chem. 278:28154-28159 (2003). [Pubmed] |
| Related annotations: | PaperBLAST |
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